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Genome-wide meta-an...
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
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Jansen, I. E. (author)
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Savage, J. E. (author)
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Watanabe, K. (author)
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show more...
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- Bryois, J. (author)
- Karolinska Institutet
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- Williams, D. M. (author)
- Karolinska Institutet
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- Steinberg, S. (author)
- Karolinska Institutet
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Sealock, J. (author)
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- Karlsson, Ida K. (author)
- Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Karolinska Institutet, Stockholm, Sweden
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Hägg, S. (author)
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Athanasiu, L. (author)
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Voyle, N. (author)
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- Proitsi, P. (author)
- Karolinska Institutet
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Witoelar, A. (author)
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Stringer, S. (author)
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- Aarsland, D. (author)
- Karolinska Institutet
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Almdahl, I. S. (author)
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Andersen, F. (author)
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Bergh, S. (author)
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Bettella, F. (author)
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Bjornsson, S. (author)
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Brækhus, A. (author)
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Bråthen, G. (author)
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de Leeuw, C. (author)
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Desikan, R. S. (author)
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Djurovic, S. (author)
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Dumitrescu, L. (author)
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Fladby, T. (author)
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Hohman, T. J. (author)
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Jonsson, P. V. (author)
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Kiddle, S. J. (author)
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Rongve, A. (author)
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Saltvedt, I. (author)
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Sando, S. B. (author)
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Selbæk, G. (author)
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Shoai, M. (author)
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Skene, N. G. (author)
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Snaedal, J. (author)
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Stordal, E. (author)
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Ulstein, I. D. (author)
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Wang, Y. (author)
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White, L. R. (author)
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Hardy, J. (author)
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- Hjerling-Leffler, J. (author)
- Karolinska Institutet
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Sullivan, P. F. (author)
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van der Flier, W. M. (author)
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Dobson, R. (author)
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Davis, L. K. (author)
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Stefansson, H. (author)
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Stefansson, K. (author)
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- Pedersen, N. L. (author)
- Karolinska Institutet
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Ripke, S. (author)
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Andreassen, O. A. (author)
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Posthuma, D. (author)
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(creator_code:org_t)
- 2019-01-07
- 2019
- English.
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In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:3, s. 404-413
- Related links:
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https://doi.org/10.1...
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https://europepmc.or...
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Abstract
Subject headings
Close
- Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we performed a large genome-wide association study of clinically diagnosed AD and AD-by-proxy (71,880 cases, 383,378 controls). AD-by-proxy, based on parental diagnoses, showed strong genetic correlation with AD (rg = 0.81). Meta-analysis identified 29 risk loci, implicating 215 potential causative genes. Associated genes are strongly expressed in immune-related tissues and cell types (spleen, liver, and microglia). Gene-set analyses indicate biological mechanisms involved in lipid-related processes and degradation of amyloid precursor proteins. We show strong genetic correlations with multiple health-related outcomes, and Mendelian randomization results suggest a protective effect of cognitive ability on AD risk. These results are a step forward in identifying the genetic factors that contribute to AD risk and add novel insights into the neurobiology of AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Jansen, I. E.
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Savage, J. E.
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Watanabe, K.
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Bryois, J.
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Williams, D. M.
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Steinberg, S.
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show more...
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Sealock, J.
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Karlsson, Ida K.
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Hägg, S.
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Athanasiu, L.
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Voyle, N.
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Proitsi, P.
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Witoelar, A.
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Stringer, S.
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Aarsland, D.
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Almdahl, I. S.
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Andersen, F.
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Bergh, S.
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Bettella, F.
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Bjornsson, S.
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Brækhus, A.
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Bråthen, G.
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de Leeuw, C.
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Desikan, R. S.
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Djurovic, S.
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Dumitrescu, L.
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Fladby, T.
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Hohman, T. J.
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Jonsson, P. V.
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Kiddle, S. J.
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Rongve, A.
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Saltvedt, I.
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Sando, S. B.
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Selbæk, G.
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Shoai, M.
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Skene, N. G.
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Snaedal, J.
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Stordal, E.
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Ulstein, I. D.
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Wang, Y.
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White, L. R.
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Hardy, J.
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Hjerling-Leffler ...
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Sullivan, P. F.
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van der Flier, W ...
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Dobson, R.
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Davis, L. K.
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Stefansson, H.
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Stefansson, K.
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Pedersen, N. L.
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Ripke, S.
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Andreassen, O. A ...
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Posthuma, D.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Nature Genetics
- By the university
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Jönköping University
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Karolinska Institutet