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Influence of single...
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Lewin, N. L.Dept Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
(author)
Influence of single nucleotide polymorphisms among cigarette smoking and non-smoking patients with coronary artery disease, urinary bladder cancer and lung cancer
- Article/chapterEnglish2021
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2021-01-28
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Public Library of Science,2021
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LIBRIS-ID:oai:DiVA.org:hj-53519
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https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-53519URI
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https://doi.org/10.1371/journal.pone.0243084DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-175439URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Funding Agencies|Jonko ping Clinical Cancer Research Foundation [110426-1]; Futurum the Academy for health and care [144631]; Medical Research Council of Southeast Sweden (FORSS) [567001]; Internal research Laboratory Medicine; Swedish Match AB
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Introduction Cigarette smoke is suggested to be a risk factor for coronary artery disease (CAD), urinary bladder cancer (UBCa) or lung cancer (LCa). However, not all heavy smokers develop these diseases and elevated cancer risk among first-degree relatives suggests an important role of genetic factor. Methods Three hundred and ten healthy blood donors (controls), 98 CAD, 74 UBCa and 38 LCa patients were included in this pilot study. The influence of 92 single nucleotide polymorphisms (SNPs) and impact of cigarette smoking were analysed. Results Out of 92 SNPs tested, differences in distribution of 14 SNPs were detected between controls and patient groups. Only CTLA4 rs3087243 showed difference in both CAD and UBCa patient group compared to control group. Stratified by smoking status, the impact of smoking was associated to frequencies of 8, 3 and 4 SNPs in CAD, UBCa, LCa patients, respectively. None of these 92 SNPs showed a statistically significant difference to more than one type of disease among smoking patients. In non-smoking patients, 7, 3 and 6 SNPs were associated to CAD, UBCa, LCa, respectively. Out of these 92 SNPs, CTLA4 rs3087243 was associated to both non-smoking CAD and UBCa. The XRCC1 rs25487 was associated to both non-smoking UBCa and LCa. Conclusion SNPs might be important risk factors for CAD, UBCa and LCa. Distribution of the SNPs was specific for each patient group, not a random event. Impact of cigarette smoking on the disease was associated to the specific SNP sequences. Thus, smoking individuals with SNPs associated to risk of these serious diseases is an important target group for smoking cessation programs.
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Karlsson, Jan-ErikLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Ryhov Hosp, Sweden(Swepub:liu)janka97
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Robinsson, D.Ryhov Hosp, Sweden
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Fagerberg, M.Dept Urology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
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Kentsson, M.Dept of Internal Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
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Sayardoust, SharielDept Periodontology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden(Swepub:hj)saysha
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Nilsson, MatsLinköpings universitet,Medicinska fakulteten,Institutionen för hälsa, medicin och vård,Academy of Health and Care, Region Jönköping, Jönköping, Sweden(Swepub:liu)matni75
(author)
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Shamoun, L.Dept Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
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Andersson, B. -Å.Dept Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
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Löfgren, S.Dept Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
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Rutqvist, L. E.Scientific Affairs Group, Swedish Match AB, Stockholm, Sweden
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Lewin, F.Dept Oncology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
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Dept Laboratory Medicine, Ryhov Hospital, Jönköping, SwedenRyhov Hosp, Sweden
(creator_code:org_t)
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In:PLOS ONE: Public Library of Science161932-6203
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Nilsson, Mats
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