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A genome-wide assoc...
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-09-07
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Springer Nature,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:hj-54690
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https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-54690URI
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https://doi.org/10.1038/s41588-021-00921-zDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147752070URI
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https://gup.ub.gu.se/publication/310534URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer’s disease have been identified. Here we show that increased sample sizes allowed identification of seven previously unidentified genetic loci contributing to Alzheimer’s disease. This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer’s disease, while identifying and prioritizing previously unidentified genes of potential interest. We anticipate that these results can be included in larger meta-analyses of Alzheimer’s disease to identify further genetic variants that contribute to Alzheimer’s pathology.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Jansen, I. E.
(author)
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Savage, J. E.
(author)
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Shadrin, A. A.
(author)
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Bahrami, S.
(author)
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Holland, D.
(author)
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Rongve, A.
(author)
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Børte, S.
(author)
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Winsvold, B. S.
(author)
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Drange, O. K.
(author)
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Martinsen, A. E.
(author)
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Skogholt, A. H.
(author)
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Willer, C.
(author)
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Bråthen, G.
(author)
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Bosnes, I.
(author)
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Nielsen, J. B.
(author)
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Fritsche, L. G.
(author)
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Thomas, L. F.
(author)
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Pedersen, L. M.
(author)
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Gabrielsen, M. E.
(author)
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Johnsen, M. B.
(author)
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Meisingset, T. W.
(author)
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Zhou, W.
(author)
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Proitsi, P.
(author)
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Hodges, A.
(author)
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Dobson, R.
(author)
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Velayudhan, L.
(author)
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Agee, M.
(author)
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Aslibekyan, S.
(author)
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Babalola, E.
(author)
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Bell, R. K.
(author)
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Bielenberg, J.
(author)
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Bryc, K.
(author)
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Bullis, E.
(author)
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Cameron, B.
(author)
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Coker, D.
(author)
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Partida, G. C.
(author)
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Dhamija, D.Karolinska Institutet
(author)
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Das, S.
(author)
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Elson, S. L.
(author)
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Filshtein, T.
(author)
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Fletez-Brant, K.
(author)
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Fontanillas, P.
(author)
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Freyman, W.
(author)
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Gandhi, P. M.
(author)
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Hicks, B.
(author)
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Hinds, D. A.
(author)
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Huber, K. E.
(author)
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Jewett, E. M.
(author)
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Jiang, Y.
(author)
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Kleinman, A.
(author)
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Kukar, K.Karolinska Institutet
(author)
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Lane, V.
(author)
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Lin, K. -H
(author)
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Lowe, M.
(author)
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Luff, M. K.
(author)
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McCreight, J. C.
(author)
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McIntyre, M. H.
(author)
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McManus, K. F.
(author)
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Micheletti, S. J.
(author)
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Moreno, M. E.
(author)
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Mountain, J. L.
(author)
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Mozaffari, S. V.
(author)
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Nandakumar, P.Karolinska Institutet
(author)
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Noblin, E. S.
(author)
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O’Connell, J.
(author)
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Petrakovitz, A. A.
(author)
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Poznik, G. D.
(author)
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Schumacher, M.
(author)
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Shastri, A. J.
(author)
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Shelton, J. F.
(author)
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Shi, J.
(author)
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Shringarpure, S.
(author)
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Tian, C.
(author)
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Tran, V.
(author)
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Tung, J. Y.
(author)
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Wang, X.
(author)
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Wang, W.
(author)
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Weldon, C. H.
(author)
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Wilton, P.
(author)
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Sealock, J. M.
(author)
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Davis, L. K.
(author)
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Pedersen, N. L.
(author)
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Reynolds, C. A.
(author)
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Karlsson, Ida K.Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping)(Swepub:hj)karida
(author)
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Magnusson, S.
(author)
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Stefansson, H.
(author)
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Thordardottir, S.
(author)
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Jonsson, P. V.
(author)
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Snaedal, J.
(author)
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Zettergren, Anna,1978Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Centre for Ageing and Health (Agecap)(Swepub:gu)xhakan
(author)
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Skoog, Ingmar,1954Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Centre for Ageing and Health (Agecap)(Swepub:gu)xskooi
(author)
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Kern, SilkeGothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Centre for Ageing and Health (Agecap)(Swepub:gu)xkersi
(author)
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Waern, Margda,1955Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Centre for Ageing and Health (Agecap)(Swepub:gu)xwaema
(author)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Stordal, E.
(author)
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Hveem, K.
(author)
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Zwart, J. -A
(author)
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Athanasiu, L.
(author)
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Selnes, P.
(author)
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Saltvedt, I.
(author)
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Sando, S. B.
(author)
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Ulstein, I.
(author)
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Djurovic, S.
(author)
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Fladby, T.
(author)
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Aarsland, D.
(author)
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Selbæk, G.
(author)
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Ripke, S.
(author)
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Stefansson, K.
(author)
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Andreassen, O. A.
(author)
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Posthuma, D.
(author)
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Team, 23andMe Research
(author)
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andMe Res, Team
(author)
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Karolinska InstitutetHHJ, Institutet för gerontologi
(creator_code:org_t)
Related titles
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In:Nature Genetics: Springer Nature53:9, s. 1276-12821061-40361546-1718
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To the university's database
- By the author/editor
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Wightman, D. P.
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Jansen, I. E.
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Savage, J. E.
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Shadrin, A. A.
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Bahrami, S.
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Holland, D.
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show more...
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Rongve, A.
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Børte, S.
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Winsvold, B. S.
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Drange, O. K.
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Martinsen, A. E.
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Skogholt, A. H.
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Willer, C.
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Bråthen, G.
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Bosnes, I.
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Nielsen, J. B.
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Fritsche, L. G.
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Thomas, L. F.
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Pedersen, L. M.
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Gabrielsen, M. E ...
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Johnsen, M. B.
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Meisingset, T. W ...
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Zhou, W.
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Proitsi, P.
-
Hodges, A.
-
Dobson, R.
-
Velayudhan, L.
-
Agee, M.
-
Aslibekyan, S.
-
Babalola, E.
-
Bell, R. K.
-
Bielenberg, J.
-
Bryc, K.
-
Bullis, E.
-
Cameron, B.
-
Coker, D.
-
Partida, G. C.
-
Dhamija, D.
-
Das, S.
-
Elson, S. L.
-
Filshtein, T.
-
Fletez-Brant, K.
-
Fontanillas, P.
-
Freyman, W.
-
Gandhi, P. M.
-
Hicks, B.
-
Hinds, D. A.
-
Huber, K. E.
-
Jewett, E. M.
-
Jiang, Y.
-
Kleinman, A.
-
Kukar, K.
-
Lane, V.
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Lin, K. -H
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Lowe, M.
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Luff, M. K.
-
McCreight, J. C.
-
McIntyre, M. H.
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McManus, K. F.
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Micheletti, S. J ...
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Moreno, M. E.
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Mountain, J. L.
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Mozaffari, S. V.
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Nandakumar, P.
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Noblin, E. S.
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O’Connell, J.
-
Petrakovitz, A. ...
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Poznik, G. D.
-
Schumacher, M.
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Shastri, A. J.
-
Shelton, J. F.
-
Shi, J.
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Shringarpure, S.
-
Tian, C.
-
Tran, V.
-
Tung, J. Y.
-
Wang, X.
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Wang, W.
-
Weldon, C. H.
-
Wilton, P.
-
Sealock, J. M.
-
Davis, L. K.
-
Pedersen, N. L.
-
Reynolds, C. A.
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Karlsson, Ida K.
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Magnusson, S.
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Stefansson, H.
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Thordardottir, S ...
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Jonsson, P. V.
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Snaedal, J.
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Zettergren, Anna ...
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Skoog, Ingmar, 1 ...
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Kern, Silke
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Waern, Margda, 1 ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Stordal, E.
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Hveem, K.
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Zwart, J. -A
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Athanasiu, L.
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Selnes, P.
-
Saltvedt, I.
-
Sando, S. B.
-
Ulstein, I.
-
Djurovic, S.
-
Fladby, T.
-
Aarsland, D.
-
Selbæk, G.
-
Ripke, S.
-
Stefansson, K.
-
Andreassen, O. A ...
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Posthuma, D.
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Team, 23andMe Re ...
-
andMe Res, Team
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Neurology
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Nature Genetics
- By the university
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Jönköping University
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Karolinska Institutet
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University of Gothenburg