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  • Nilsson, Anna-LenaLund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups (author)

Relationship between Ljungan virus antibodies, HLA-DQ8, and insulin autoantibodies in newly diagnosed type 1 diabetes children

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • Mary Ann Liebert, Inc.2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:hkr-12678
  • urn:nbn:se:hkr:diva-12678urn
  • https://doi.org/10.1089/vim.2013.0008DOI
  • https://lup.lub.lu.se/record/3979893URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Environmental factors, including viral infections, may explain an increasing and fluctuating incidence of childhood type 1 diabetes (T1D). Ljungan virus (LV) isolated from bank voles have been implicated, but it is unclear whether LV contributes to islet autoimmunity, progression to clinical onset, or both, of T1D. The aim was to test whether LV antibodies (LVAb) were related to HLA-DQ and islet autoantibodies in newly diagnosed T1D patients (n = 676) and controls (n = 309). Patients, 0-18 years of age, diagnosed with T1D in 1996-2005 were analyzed for LVAb, HLA-DQ genotypes, and all seven known islet autoantibodies (GADA, IA-2A, IAA, ICA, ZnT8RA, ZnT8WA, and ZnT8QA). LVAb at 75th percentile, defined as cut off, was 90 (range 6-3936) U/mL and 4th quartile LVAb were found in 25% (170/676) of which 64% were < 10 (n = 108, p < 0.0001), and 27% were < 5 (n = 45; p < 0.0001) years old. The 4th quartile LVAb in children < 10 years of age correlated to HLA DQ2/8, 8/8, and 8/X (p < 0.0001). Furthermore, in the group with 4th quartile LVAb, 55% were IAA positive (p = 0.01) and correlation was found between 4th quartile LVAb and IAA in children < 10 years of age (p = 0.035). It is concluded that 1) LVAb were common among the young T1D patients and LVAb levels were higher in the younger age groups; 2) 4th quartile LVAb correlated with IAA; and 3) there was a correlation between 4th quartile LVAb and HLA-DQ8, particularly in the young patients. The presence of LVAb supports the notion that prior exposure to LV may be associated with T1D.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Vaziri-Sani, FaribaLund University(Swepub:hkr)vazfar (author)
  • Andersson, CeciliaLund University (author)
  • Larsson, KarinLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups (author)
  • Carlsson, AnneliLund University (author)
  • Cedervall, ElisabethÄngelholm Hospital (author)
  • Jönsson, BjörnYstad Hospital (author)
  • Neiderud, JanHelsingborg Hospital (author)
  • Elding Larsson, HelenaLund University (author)
  • Ivarsson, Sten-AndersLund University (author)
  • Lernmark, AkeLund University (author)
  • Vaziri Sani, FaribaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Diabetes and Celiac Unit,Lund University Research Groups(Swepub:lu)fa3255va (author)
  • Larsson, HelenaLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups(Swepub:lu)pedi-hla (author)
  • Andersson, Cecilia KLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups(Swepub:lu)med-cao (author)
  • Jonsson, Bjorn (author)
  • Carlsson, AnnelieLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-acs (author)
  • Lernmark, ÅkeLund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups(Swepub:lu)endo-ale (author)
  • Ivarsson, StenLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups(Swepub:lu)pedi-siv (author)
  • Diabetes och celiakiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Viral immunology: Mary Ann Liebert, Inc.26:3, s. 207-2150882-82451557-8976

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