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Determination of thirteen antibiotics in drug products : a new LC-MS/MS tool for screening drug product quality

Oppong Bekoe, Samuel (author)
Faculty of Health and Medical Sciences, University of Copenhagen
Bak, Søren Alex (author)
Faculty of Health and Medical Sciences, University of Copenhagen
Björklund, Erland (author)
Högskolan Kristianstad,Plattformen för molekylär analys,Avdelningen för miljö- och biovetenskap,Forskningsmiljön MoLab,Faculty of Health and Medical Sciences, University of Copenhagen
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Krogh, Kristine A. (author)
Faculty of Health and Medical Sciences, University of Copenhagen
Okine, Nathaniel N. N. A. (author)
Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Adosraku, Reimmiel K. (author)
Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Styrishave, Bjarne (author)
Faculty of Health and Medical Sciences, University of Copenhagen
Hansen, Martin (author)
Faculty of Health and Medical Sciences, University of Copenhagen
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 (creator_code:org_t)
2014
2014
English.
In: Analytical Methods. - 1759-9660 .- 1759-9679. ; 6, s. 5847-5855
Related links:
https://doi.org/10.1...
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Poor quality antibiotic medicines in circulation in Sub-Saharan Africa continue to be a burden. Pharmaceutical trade in substandard and counterfeit medicines is on the rise. The chemical quality of antibiotics dispensed in health facilities and recognised drug outlets in Ghana, when compromised, could be a major drawback to efforts made in fighting antibiotic resistance globally. To improve on antibiotic drug quality monitoring, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodology, which is capable of quantifying thirteen antibiotics in drug products, was developed and validated in present work. The methodology was applied to various drug products including tablets, capsules, suspensions, syrups, intravenous and injection solutions as well as ear and eye droplets used as essential medicines in a Sub-Saharan country, Ghana.

Subject headings

NATURAL SCIENCES  -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
NATURVETENSKAP  -- Kemi -- Analytisk kemi (hsv//swe)
NATURVETENSKAP  -- Kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

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ref (subject category)
art (subject category)

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