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  • Araujo de Pina Cabral, DBBrasilien (author)

Prospective evaluation of glutamine and phospholipids levels in first degree relatives of patients with Type 1 Diabetes from a multiethnic population

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • BioMed Central (BMC),2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:hkr-15864
  • urn:nbn:se:hkr:diva-15864urn
  • https://doi.org/10.1186/s13098-015-0048-xDOI
  • https://lup.lub.lu.se/record/7485224URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • gratis
  • BACKGROUND: A dysregulation in the metabolism of lipids may be an early marker of autoimmunity in Type 1 Diabetes (T1D). It would be of general importance to identify metabolic patterns that would predict the risk for T1D later in life. The aim of this study was to perform a prospective evaluation of glutamine and phospholipids levels in Brazilian first degree relatives (FDR) of patients with T1D in a mean interval of 5 years.FINDINGS: Brazilian FDR (n = 30) of patients with T1D were evaluated and blood was sampled to measure the levels of glutamine and phospholipids in the fasting serum by quantitative colorimetric method. The tests were repeated after a mean interval of 5 years and compared to a control group (n = 20). The FDR presented lower levels of phospholipids than controls (p = 0.028), but not of glutamine (p = 0.075). Phospholipids levels decreased over time (p = 0.028) in FDR and were associated with Glutamic acid decarboxylase autoantibody (GADA) titers (p = 0.045), autoantibody positivity (p = 0.008) and PTPN22 polymorphisms (p = 0.014).CONCLUSIONS: In this Brazilian multiethnic population, there was a significant decrease in phospholipids levels in FDR in patients with T1D during a 5-year prospective follow-up, as well as a significant association between these metabolite, GADA and PTPN22 polymorphisms. For Glutamine no difference was found. These findings suggest that a dysregulation in the metabolism of lipids may precede the onset of the autoimmunity in T1D.

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  • Dantas, JRBrasilien (author)
  • Skärstrand, HLund University (author)
  • Barone, BBrasilien (author)
  • Carvalho, FBrasilien (author)
  • Tortora, RBrasilien (author)
  • Milech, ABrasilien (author)
  • Vaziri-Sani, FaribaLunds universitet(Swepub:hkr)vazfar (author)
  • Oliveira, JEBrasilien (author)
  • Zajdenverg, LBrasilien (author)
  • Rodacki, MBrasilien (author)
  • Vaziri Sani, FaribaLund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups(Swepub:lu)fa3255va (author)
  • Oliveira, J E P (author)
  • Araujo de Pina Cabral, D B (author)
  • Dantas, J R (author)
  • Skärstrand, HannaLund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups(Swepub:lu)med-hsk (author)
  • BrasilienLund University (creator_code:org_t)

Related titles

  • In:Diabetology and Metabolic Syndrome: BioMed Central (BMC)7:521758-59961758-5996

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