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The severity of hum...
The severity of human peri-implantitis lesions correlates with the level of submucosal microbial sysbiosis
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- Kröger, A (author)
- Tyskland & England
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- Hülsmann, C (author)
- Tyskland
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- Fickl, S (author)
- Tyskland
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- Spinell, T (author)
- Tyskland & Italien
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- Hüttig, F (author)
- Tyskland
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- Kaufmann, F (author)
- Tyskland
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- Heimbach, A (author)
- Tyskland
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- Hoffmann, P (author)
- Tyskland
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- Enkling, N (author)
- Tyskland
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- Renvert, Stefan (author)
- Högskolan Kristianstad,Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL),Avdelningen för oral hälsa
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- Schwarz, F (author)
- Tyskland
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- Demmer, Ryan T (author)
- USA
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- Papapanou, P N (author)
- USA
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- Jepsen, S (author)
- Tyskland
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- Kebschull, M (author)
- USA & Tyskland
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(creator_code:org_t)
- 2018
- 2018
- English.
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In: Journal of Clinical Periodontology. - 0303-6979 .- 1600-051X. ; 45:12, s. 1498-1509
- Related links:
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http://pure-oai.bham...
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https://doi.org/10.1...
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Abstract
Subject headings
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- AIM: To cross-sectionally analyze the submucosal microbiome of peri-implantitis (PI) lesions at different severity levels.MATERIALS AND METHODS: Microbial signatures of 45 submucosal plaque samples from untreated peri-implantitis lesions obtained from 30 non-smoking, systemically healthy subjects were assessed by 16s sequencing. Linear mixed models were used to identify taxa with differential abundance by probing depth, after correction for age, gender, and multiple samples per subject. Network analyses were performed to identify groups of taxa with mutual occurrence or exclusion. Subsequently, the effects of peri-implant probing depth on submucosal microbial dysbiosis was calculated using the microbial dysbiosis index.RESULTS: In total, we identified 337 different taxa in the submucosal microbiome of peri-implantitis. Total abundance of 12 taxa correlated significantly with increasing probing depth; a significant relationship with lower probing depth was found for 16 taxa. Network analysis identified two mutually exclusive complexes associated with shallow pockets and deeper pockets, respectively. Deeper peri-implant pockets were associated with significantly increased dysbiosis.CONCLUSION: Increases in peri-implant pocket depth are associated with substantial changes in the submucosal microbiome and increasing levels of dysbiosis. This article is protected by copyright. All rights reserved.
Subject headings
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- NGS
- 16s
- dysbiosis
- microbiome
- next generation sequencing
- peri-implant disease
- peri-implantitis
Publication and Content Type
- ref (subject category)
- art (subject category)
- By the author/editor
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Kröger, A
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Hülsmann, C
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Fickl, S
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Spinell, T
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Hüttig, F
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Kaufmann, F
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show more...
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Heimbach, A
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Hoffmann, P
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Enkling, N
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Renvert, Stefan
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Schwarz, F
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Demmer, Ryan T
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Papapanou, P N
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Jepsen, S
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Kebschull, M
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dentistry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Journal of Clini ...
- By the university
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Kristianstad University College