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Apomorphine formula...
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Hagell, PeterHögskolan Kristianstad,Forskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education,Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap
(author)
Apomorphine formulation may influence subcutaneous complications from continuous subcutaneous apomorphine infusion in Parkinson's disease
- Article/chapterEnglish2020
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:hkr-20859
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urn:nbn:se:hkr:diva-20859urn
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https://doi.org/10.1007/s00415-020-10031-1DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:144085273URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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gratis
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Continuous subcutaneous (s.c.) apomorphine infusion is an effective therapy for Parkinson's disease (PD), but a limitation is the formation of troublesome s.c. nodules. Various chemically non-identical apomorphine formulations are available. Anecdotal experiences have suggested that shifting from one of these (Apo-Go PumpFill®; apoGPF) to another (Apomorphine PharmSwed®; apoPS) may influence the occurrence and severity of s.c. nodules. We, therefore, followed 15 people with advanced PD (median PD-duration, 15 years; median "off"-phase Hoehn and Yahr, IV) on apoGPF and with troublesome s.c. nodules who were switched to apoPS. Data were collected at baseline, at the time of switching, and at a median of 1, 2.5, and 7.3 months post-switch. Total nodule numbers (P < 0.001), size (P < 0.001), consistency (P < 0.001), skin changes (P = 0.058), and pain (P ≤ 0.032) improved over the observation period. PD severity and dyskinesias tended to improve and increase, respectively. Apomorphine doses were stable, but levodopa doses increased by 100 mg/day. Patient-reported apomorphine efficacy tended to increase and all participants remained on apoPS throughout the observation period; with the main patient-reported reason being improved nodules. These observations suggest that patients with s.c. nodules caused by apoGPF may benefit from switching to apoPS in terms of s.c. nodule occurrence and severity. Alternatively, observed benefits may have been due to the switch itself. As nodule formation is a limiting factor in apomorphine treatment, a controlled prospective study comparing local tolerance with different formulations is warranted.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Höglund, ArjaKarolinska universitetssjukhuset
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Hellqvist, CarinaUniversitetssjukhuset i Linköping
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Johansson, Eva-LenaCentralsjukhuset i Karlstad
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Löwed, BeritCentralsjukhuset i Karlstad
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Sjöström, Anne-ChristineSahlgrenska universitetsjukhuset
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Karlberg, CarinaSahlgrenska universitetsjukhuset
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Lundgren, MargarethKarolinska universitetssjukhuset
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Dizdar, NilLinköpings universitet
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Johansson, AndersKarolinska universitetssjukhuset
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Willows, ThomasKarolinska universitetssjukhuset
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Rådberg, JohanCentralsjukhuset i Karlstad
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Bergquist, FilipSahlgrenska universitetssjukhuset
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Karlberg, C
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Hellqvist, C
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Lowed, B
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Willows, T
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Radberg, J
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Bergquist, F
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Dizdar, N
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Hoglund, AKarolinska Institutet
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Lundgren, M
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Hagell, P
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Sjostrom, AC
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Johansson, EL
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Johansson, AKarolinska Institutet
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Högskolan KristianstadForskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education
(creator_code:org_t)
Related titles
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In:Journal of Neurology267:11, s. 3411-34170340-53541432-1459
Internet link
- By the author/editor
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Hagell, Peter
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Höglund, Arja
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Hellqvist, Carin ...
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Johansson, Eva-L ...
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Löwed, Berit
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Sjöström, Anne-C ...
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show more...
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Karlberg, Carina
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Lundgren, Margar ...
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Dizdar, Nil
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Johansson, Ander ...
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Willows, Thomas
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Rådberg, Johan
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Bergquist, Filip
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Karlberg, C
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Hellqvist, C
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Lowed, B
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Willows, T
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Radberg, J
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Bergquist, F
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Dizdar, N
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Hoglund, A
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Lundgren, M
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Hagell, P
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Sjostrom, AC
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Johansson, EL
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Johansson, A
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Journal of Neuro ...
- By the university
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Kristianstad University College
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Karolinska Institutet