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Restitution of neur...
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Lindgren, M.Department of Clinical Neurophysiology, Lund University and University Hospital
(author)
Restitution of neurophysiological functions, performance, and subjective symptoms after moderate insulin-induced hypoglycaemia in non-diabetic men
- Article/chapterEnglish1996
Publisher, publication year, extent ...
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Wiley-Blackwell,1996
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:hkr-647
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urn:nbn:se:hkr:diva-647urn
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https://doi.org/10.1002/(SICI)1096-9136(199603)13:3<218::AID-DIA25>3.0.CO;2-DDOI
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https://lup.lub.lu.se/record/1110229URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The restoration of cognitive function was studied in 10 healthy men aged 26 years (25.5 +/- 1.2 years; mean +/- SD) after insulin-induced hypoglycaemia (arterialized blood glucose 2.5 +/- 0.4 mmol l-1) for 62 +/- 8 min. Another group of six men participated in a single blind sham study for comparison. The hypoglycaemic event caused a significant increase (p = 0.006) in serum adrenaline levels. Ratings of adrenergically mediated symptoms increased during hypoglycaemia (p = 0.006), as did neuroglycopenic symptoms (p = 0.002), although neuroglycopenia ratings increased in both studies. During hypoglycaemia, P300 amplitudes in a relatively demanding visual search task decreased (p = 0.02), whereas easier tasks were unaffected. The amplitudes were restored after 40 min of normoglycaemia. Reaction time deteriorated after restoration of normoglycaemia, suggesting an effect of hypoglycaemia on learning. Thus, hypoglycaemia at a blood glucose level that is common among patients treated with insulin causes clear cognitive dysfunction, although restoration of the cognitive dysfunction to normal was fast.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Eckert, B.Department of Internal Medicine, Lund University and University Hospital
(author)
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Stenberg, Georg,1947-Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
(author)
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Agardh, C. D.Department of Internal Medicine, Lund University and University Hospital
(author)
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Agardh, Carl-DavidLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-cag
(author)
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Lindgren, M
(author)
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Eckert, B
(author)
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Department of Clinical Neurophysiology, Lund University and University HospitalDepartment of Internal Medicine, Lund University and University Hospital
(creator_code:org_t)
Related titles
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In:Diabetic Medicine: Wiley-Blackwell13:3, s. 218-250742-30711464-5491
Internet link