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Similar appearance,...
Similar appearance, different mechanisms : xerosis in HIV, atopic dermatitis and ageing
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- Mischo, Meike (author)
- Ruhr Univ Bochum, Bochum, Germany.
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- von Kobyletzki, Laura B (author)
- Lund University,Lunds universitet,Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Lund Univ, Skne Univ Hosp, Dept Dermatol, Inst Clin Res Malmo, Malmo, Sweden.;Karlstad Univ, Dept Publ Hlth Sci, Karlstad, Sweden.,Dermatologi,Forskargrupper vid Lunds universitet,Dermatology,Lund University Research Groups
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- Bruendermann, Erik (author)
- Ruhr Univ Bochum, Bochum, Germany.
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- Schmidt, Diedrich A. (author)
- Ruhr Univ Bochum, Bochum, Germany.
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- Potthoff, Anja (author)
- Ruhr Univ Bochum, Dept Dermatol, Bochum, Germany.
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- Brockmeyer, Norbert H. (author)
- Ruhr Univ Bochum, Dept Dermatol, Bochum, Germany.;Ruhr Univ Bochum, Competence Network HIV Aids, Bochum, Germany.
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- Havenith, Martina (author)
- Ruhr Univ Bochum, Bochum, Germany.
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Ruhr Univ Bochum, Bochum, Germany Institutionen för hälsovetenskaper (from 2013) (creator_code:org_t)
- 2014-05-28
- 2014
- English.
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In: Experimental dermatology. - : Wiley. - 0906-6705 .- 1600-0625. ; 23:6, s. 446-448
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Xerosis is one of the most common dermatologic disorders occurring in the elderly and in patients with atopic dermatitis (AD) and human immunodeficiency virus (HIV) infection. Xerosis has been linked to an impaired skin barrier function of the stratum corneum. Using Raman microspectroscopy, we concentrated on deeper skin layers, viable epidermis and dermis of 47 volunteers and associated molecular alterations to the evolution of xerosis and the skin barrier, for example, lipid, water and antioxidant content. A decrease in lipids within the viable epidermis is found for elderly and HIV-patients. Lipid and water values of AD patients and their healthy reference group are similar. Decreases in lipids and simultaneous increases in water are found in the dermis for HIV and AD patients in comparison to their healthy reference groups. Excessive levels of epidermal carotenoids, mainly lycopene, in HIV-patients were found potentially leading to adverse effects such as premature skin ageing.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- atopic dermatitis
- HIV
- molecular composition
- Raman
- xerosis
- Public Health Science
- Folkhälsovetenskap
- atopic dermatitis
- HIV
- molecular composition
- Raman
- xerosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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