Search: onr:"swepub:oai:DiVA.org:kau-71932" >
M2 macrophages and ...
M2 macrophages and regulatory T cells in lethal prostate cancer.
-
- Erlandsson, Ann, 1968- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology,Örebro University
-
- Carlsson, Jessica, 1984- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology,Örebro University
-
- Lundholm, Marie, 1974- (author)
- Umeå universitet,Patologi,Umeå University
-
show more...
-
- Fält, Anna (author)
- School of Medical Sciences, Örebro University, Örebro, Sweden,Clinical Epidemiology and Biostatistics
-
- Andersson, Sven-Olof (author)
- Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
- Andrén, Ove, 1963- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology,Örebro University
-
- Davidsson, Sabina, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology,Örebro University
-
show less...
-
(creator_code:org_t)
- 2018-11-30
- 2019
- English.
-
In: The Prostate. - : John Wiley & Sons. - 0270-4137 .- 1097-0045. ; 79:4, s. 363-369
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://kau.diva-por... (primary) (Raw object)
-
https://onlinelibrar...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Prostate cancer (PCa) is one of the most frequently diagnosed cancers in the world. Emerging evidence suggests that inflammatory cells such as M2 macrophages and regulatory T cells (Tregs ) can contribute to cancer progression by suppressing the anti-tumor immune response. This study investigated the number of CD163-positive M2 macrophages in PCa tissue. It also investigated the correlation and interaction of M2 macrophages and Tregs .METHODS: This nested case-control study included subjects from a cohort of men diagnosed with PCa as an incidental finding during transurethral resection of the prostate. The cases were 225 men who died from PCa, and the controls were 367 men who survived more than 10 years after PCa diagnosis without disease progression. Infiltrating CD163-positive M2 macrophages and FOXP3/CD4-positive Tregs in PCa tissue were identified using immunohistochemistry. The correlation and interaction of M2 macrophages and Tregs were assessed using Spearman's rank-order correlation and a likelihood test, respectively. Logistic regression was used to estimate odds ratios (ORs) for lethal PCa and macrophage counts.RESULTS: The number of M2 macrophages and Tregs showed a significant correlation (P < 0.001) but no interactions. The OR for lethal PCa was 1.93 (95%CI: 1.23-3.03) for men with high numbers of M2 macrophages. Also for cases with uncertain outcome (GS categories 3 + 4 and 4 + 3) high numbers of M2 macrophages does predict a poorer prognosis.CONCLUSIONS: Our data showed that men with high numbers of M2 macrophages in the prostate tumor environment had increased odds of dying of PCa. It is possible that M2 macrophages, together with other suppressor cells such as Tregs , promote an immunosuppressive environment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- CD163
- FOXP3
- TAMs
- Tregs
- Public Health Science
- Folkhälsovetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Erlandsson, Ann, ...
-
Carlsson, Jessic ...
-
Lundholm, Marie, ...
-
Fält, Anna
-
Andersson, Sven- ...
-
Andrén, Ove, 196 ...
-
show more...
-
Davidsson, Sabin ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Urology and Neph ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
The Prostate
- By the university
-
Karlstad University
-
Örebro University
-
Umeå University