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  • Levie, DeborahErasmus MC, Dept Internal Med, Acad Rotterdam, Netherlands.;Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands.;Erasmus MC Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands. (author)

The Association of Maternal Iodine Status in Early Pregnancy with Thyroid Function in the Swedish Environmental Longitudinal, Mother and Child, Asthma and Allergy Study

  • Article/chapterEnglish2019

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  • Mary Ann Liebert,2019
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:kau-75614
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-75614URI
  • https://doi.org/10.1089/thy.2019.0164DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-175808URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Background: Severe maternal iodine deficiency can impact fetal brain development through effects on maternal and/or fetal thyroid hormone availability. The effects of mild-to-moderate iodine deficiency on thyroid function are less clear. The aim was to investigate the association of maternal urinary iodine concentration corrected for creatinine (UI/Creat) with thyroid function and autoantibodies in a mild-to-moderate iodine-deficient pregnant population. Methods: This study was embedded within the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study. Clinical reference ranges were determined by the 2.5th and 97.5th population-based percentile cutoffs. The associations of UI/Creat with thyrotropin (TSH), free thyroxine (fT4), free triiodothyronine (fT3), total T4 (TT4), and total T3 (TT3) were studied using multivariable linear regression in thyroid peroxidase antibody (TPOAb)-negative women. The association of UI/Creat with TPOAb and thyroglobulin antibody (TgAb) positivity was analyzed using multivariable logistic regression. Results: Urinary iodine and thyroid function were measured at a median (95% range) gestational age of 10 (6-14) weeks in 2009 women. The median (95% range) UI/Creat was 85 mu g/g (36-386) and the UI/Creat was below 150 mu g/g in 80.1% of women. Reference ranges did not differ substantially by UI/Creat. A lower UI/Creat was associated with a lower TSH (p = 0.027), a higher TT4 (p = 0.032), and with a corresponding trend toward slightly higher fT4 (p = 0.081), fT3 (p = 0.079), and TT3 (p = 0.10). UI/Creat was not associated with the fT4/fT3 (p = 0.94) or TT4/TT3 ratios (p = 0.63). Women with a UI/Creat of 150-249 mu g/g had the lowest prevalence of TPOAb positivity (6.1%), while women with a UI/Creat of <150 mu g/g had a higher prevalence (11.0%, odds ratio [OR] confidence interval [95% CI] 1.84 [1.07-3.20], p = 0.029). Women with a UI/Creat >= 500 mu g/g showed the highest prevalence and a higher risk of TPOAb positivity, however, only a small proportion of women had such a UI/Creat (12.5%, OR, [95% CI] 2.36 [0.54-10.43], p = 0.26). Conclusions: We could not identify any meaningful differences in thyroid function reference ranges. Lower iodine availability was associated with a slightly lower TSH and a higher TT4. Women with adequate iodine intake had the lowest risk of TPOAb positivity.

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  • Derakhshan, ArashErasmus MC, Dept Internal Med, Acad Ctr Thyroid Dis, Rotterdam, Netherlands. (author)
  • Shu, HuanStockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Stockholm University(Swepub:su)hush5382 (author)
  • Broeren, Maarten A. C.Maxima Med Ctr, Lab Clin Chem & Haematol, Veldhoven, Netherlands. (author)
  • de Poortere, Ralph A.Maxima Med Ctr, Lab Clin Chem & Haematol, Veldhoven, Netherlands. (author)
  • Peeters, Robin P.Erasmus MC, Dept Internal Med, Rotterdam, Netherlands. (author)
  • Bornehag, Carl-Gustaf,1957-Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn Sch Med Mt Sinai, New York, NY(Swepub:kau)caguborn (author)
  • Demeneix, BarbaraSorbonne Univ7ersity, France. (author)
  • Korevaar, Tim I. M.Erasmus MC, Dept Internal Med, Rotterdam, Netherlands. (author)
  • Erasmus MC, Dept Internal Med, Acad Rotterdam, Netherlands.;Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands.;Erasmus MC Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands.Erasmus MC, Dept Internal Med, Acad Ctr Thyroid Dis, Rotterdam, Netherlands. (creator_code:org_t)

Related titles

  • In:Thyroid: Mary Ann Liebert29:11, s. 1660-16681050-72561557-9077

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