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Immune function and...
Immune function and response to neoadjuvant chemotherapy in hormone receptor positive, HER2-negative breast cancer
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- Matikas, A. (author)
- Karolinska Institutet
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- Lovrot, J. (author)
- Karolinska Institutet
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- Ramberg, A. (author)
- Cent Hosp Karlstad
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- Eriksson, M. (author)
- Cent Hosp Karlstad
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- Lindsten, T. (author)
- Cent Hosp Karlstad
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- Lekberg, T. (author)
- Karolinska Institutet
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- Hedenfalk, I. (author)
- Lund University
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- Loman, N. (author)
- Lund University
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- Bergh, J. (author)
- Karolinska Institutet
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- Erlandsson, Ann, 1968- (author)
- Örebro University
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- Hatschek, T. (author)
- Karolinska Institutet
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- Foukakis, T. (author)
- Karolinska Institutet
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(creator_code:org_t)
- Oxford University Press, 2017
- 2017
- English.
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In: Annals of Oncology. - : Oxford University Press. - 0923-7534 .- 1569-8041. ; 28
- Related links:
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https://urn.kb.se/re...
Abstract
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- BackgroundGene expression (GE) signatures and Tumor Infiltrating Lymphocyte (TILs) enumeration have shown promise as predictors of response to neoadjuvant chemotherapy in Hormone Receptor negative (HR-) and HER2+, but not in HR+/HER2- breast cancer (BC). This study aimed to explore their predictive value in HR+/HER2- BC, based on previous work from our group on the association of immune function and chemosensitivity in advanced HR+ BC.MethodsThe PROMIX phase 2 trial enrolled patients with locally advanced HER2- BC to receive six cycles of epirubicin and docetaxel, plus bevacizumab during cycles 3-6. Patients underwent tumor biopsies at baseline and after cycle 2 for GE profiling using DNA microarrays and TIL enumeration according to standard guidelines. Since pathologic complete remission (pCR) is relatively rare in HR+ BC, we also associated an immune gene module score (IMS) and TIL counts with the non-dichotomous variable of decrease in tumor size.ResultsOf the 150 enrolled patients, n = 113 were HR+. For n = 71, both TIL and GE data were available at baseline, while for n = 78 and n = 49 patients longitudinal TIL and GE data at baseline and cycle 2 were available, respectively. At baseline, on both univariate (OR = 2.29, P = 0.037) and multivariate analysis (OR = 2.35, P = 0.044) IMS was associated with pCR, while its association with tumor shrinkage was only apparent on univariate (P = 0.047) and not multivariate analysis (P = 0.061). TIL infiltration >50% (n = 9) was associated with neither pCR (OR = 1.812, P = 0.61) nor tumor shrinkage (P = 0.99). However, decreases in TIL counts in cycle 2 compared with baseline were associated with lesser decreases in tumor size (P = 0.043 for univariate and P = 0.044 for multivariate analysis).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Biology
- Biologi
Publication and Content Type
- vet (subject category)
- art (subject category)
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- By the author/editor
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Matikas, A.
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Lovrot, J.
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Ramberg, A.
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Eriksson, M.
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Lindsten, T.
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Lekberg, T.
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show more...
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Hedenfalk, I.
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Loman, N.
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Bergh, J.
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Erlandsson, Ann, ...
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Hatschek, T.
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Foukakis, T.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Annals of Oncolo ...
- By the university
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Karlstad University