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Quasi-potential landscape in complex multi-stable systems
- Zhou, Joseph Xu (author)
- Aliyu, M. D. S. (author)
-
- Aurell, Erik (author)
- KTH,Beräkningsbiologi, CB
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- Huang, Sui (author)
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- (creator_code:org_t)
- 2012-08-29
- 2012
- English.
- In: Journal of the Royal Society Interface. - : The Royal Society. - 1742-5689 .- 1742-5662. ; 9:77, s. 3539-3553
- Journal article (peer-reviewed)
Abstract
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- The developmental dynamics of multicellular organisms is a process that takes place in a multi-stable system in which each attractor state represents a cell type, and attractor transitions correspond to cell differentiation paths. This new understanding has revived the idea of a quasi-potential landscape, first proposed by Waddington as a metaphor. To describe development, one is interested in the 'relative stabilities' of N attractors (N > 2). Existing theories of state transition between local minima on some potential landscape deal with the exit part in the transition between two attractors in pair-attractor systems but do not offer the notion of a global potential function that relates more than two attractors to each other. Several ad hoc methods have been used in systems biology to compute a landscape in non-gradient systems, such as gene regulatory networks. Here we present an overview of currently available methods, discuss their limitations and propose a new decomposition of vector fields that permits the computation of a quasi-potential function that is equivalent to the Freidlin-Wentzell potential but is not limited to two attractors. Several examples of decomposition are given, and the significance of such a quasi-potential function is discussed.
Subject headings
- SAMHÄLLSVETENSKAP -- Annan samhällsvetenskap -- Tvärvetenskapliga studier inom samhällsvetenskap (hsv//swe)
- SOCIAL SCIENCES -- Other Social Sciences -- Social Sciences Interdisciplinary (hsv//eng)
Keyword
- multi-stable dynamical system
- non-equilibrium dynamics
- quasi-potential
- state transition
- epigenetic landscape
- Freidlin-Wentzell theory
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Zhou, Joseph Xu
- Aliyu, M. D. S.
- Aurell, Erik
- Huang, Sui
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