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pH-triggered self-a...
pH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers
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Lundberg, Pontus (author)
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Lynd, Nathaniel A. (author)
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Zhang, Yuning (author)
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Zeng, Xianghui (author)
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Krogstad, Daniel V. (author)
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Paffen, Tim (author)
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- Malkoch, Michael (author)
- KTH,Ytbehandlingsteknik
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Nyström, Andreas M. (author)
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Hawker, Craig J. (author)
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(creator_code:org_t)
- 2013
- 2013
- English.
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In: Soft Matter. - : Royal Society of Chemistry (RSC). - 1744-683X .- 1744-6848. ; 9:1, s. 82-89
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Histamine functionalized poly(allyl glycidyl ether)-b-poly(ethylene glycol)-b-poly(allyl glycidyl ether) (PAGE-PEO-PAGE) triblock copolymers represent a new class of physically cross-linked, pH-responsive hydrogels with significant potential for biomedical applications. These telechelic triblock copolymers exhibited abrupt and reversible hydrogelation above pH 7.0 due to a hydrophilic/hydrophobic transition of the histamine units to form a network of hydrophobic domains bridged by a hydrophilic PEO matrix. These hydrophobic domains displayed improved ordering upon increasing pH and self-assembled into a body centered cubic lattice at pH 8.0, while at lower concentrations formed well-defined micelles. Significantly, all materials were found to be non-toxic when evaluated on three different cell lines and suggests a range of medical and biomedical applications.
Subject headings
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
Keyword
- Drug-Delivery
- Hydrogels
- Gels
- Polymer
- Therapeutics
- Proteins
- Biology
- Driven
- Cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
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