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Comprehensive analysis of the genome transcriptome and proteome landscapes of three tumor cell lines
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- Akan, Pelin (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Alexeyenko, Andrey (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Costea, Paul Igor (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Hallman, Jimmie (author)
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- (creator_code:org_t)
- Springer Science and Business Media LLC, 2012
- 2012
- English.
- In: Genome Medicine. - : Springer Science and Business Media LLC. - 1756-994X. ; 4, s. 86-
- Journal article (peer-reviewed)
Abstract
Subject headings
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- We here present a comparative genome, transcriptome and functional network analysis of three human cancer cell lines (A431, U251MG and U2OS), and investigate their relation to protein expression. Gene copy numbers significantly influenced corresponding transcript levels; their effect on protein levels was less pronounced. We focused on genes with altered mRNA and/or protein levels to identify those active in tumor maintenance. We provide comprehensive information for the three genomes and demonstrate the advantage of integrative analysis for identifying tumor-related genes amidst numerous background mutations by relating genomic variation to expression/protein abundance data and use gene networks to reveal implicated pathways.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Medicinsk bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- human myt1
- gene
- cancer
- networks
- mutations
- coactivator
- pathways
- p53
- establishment
- expression
Publication and Content Type
- ref (subject category)
- art (subject category)
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