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First application o...
First application of liquid-metal-jet sources for small-animal imaging : High-resolution CT and phase-contrast tumor demarcation
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- Larsson, Daniel H. (author)
- KTH,Biomedicinsk fysik och röntgenfysik
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- Lundström, Ulf (author)
- KTH,Biomedicinsk fysik och röntgenfysik
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- Westermark, Ulrica K. (author)
- Karolinska Institutet
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- Arsenian Henriksson, Marie (author)
- Karolinska Institutet
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- Burvall, Anna (author)
- KTH,Biomedicinsk fysik och röntgenfysik
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- Hertz, Hans M. (author)
- KTH,Biomedicinsk fysik och röntgenfysik
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(creator_code:org_t)
- 2013-01-24
- 2013
- English.
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In: Medical physics (Lancaster). - : Wiley. - 0094-2405 .- 2473-4209. ; 40:2, s. 021909-
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Purpose: Small-animal studies require images with high spatial resolution and high contrast due to the small scale of the structures. X-ray imaging systems for small animals are often limited by the microfocus source. Here, the authors investigate the applicability of liquid-metal-jet x-ray sources for such high-resolution small-animal imaging, both in tomography based on absorption and in soft-tissue tumor imaging based on in-line phase contrast. Methods: The experimental arrangement consists of a liquid-metal-jet x-ray source, the small-animal object on a rotating stage, and an imaging detector. The source-to-object and object-to-detector distances are adjusted for the preferred contrast mechanism. Two different liquid-metal-jet sources are used, one circulating a Ga/In/Sn alloy and the other an In/Ga alloy for higher penetration through thick tissue. Both sources are operated at 40-50 W electron-beam power with similar to 7 mu m x-ray spots, providing high spatial resolution in absorption imaging and high spatial coherence for the phase-contrast imaging. Results: High-resolution absorption imaging is demonstrated on mice with CT, showing 50 mu m bone details in the reconstructed slices. High-resolution phase-contrast soft-tissue imaging shows clear demarcation of mm-sized tumors at much lower dose than is required in absorption. Conclusions: This is the first application of liquid-metal-jet x-ray sources for whole-body small-animal x-ray imaging. In absorption, the method allows high-resolution tomographic skeletal imaging with potential for significantly shorter exposure times due to the power scalability of liquid-metal-jet sources. In phase contrast, the authors use a simple in-line arrangement to show distinct tumor demarcation of few-mm-sized tumors. This is, to their knowledge, the first small-animal tumor visualization with a laboratory phase-contrast system.
Subject headings
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- small-animal imaging
- liquid-metal-jet
- x-ray
- CT
- tumor demarcation
- mouse
Publication and Content Type
- ref (subject category)
- art (subject category)
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