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The importance of a...
The importance of an endotoxin-free environment during the production of nanoparticles used in medical applications
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- Vallhov, Helen (author)
- Karolinska Institutet
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- Qin, Jian (author)
- KTH,Funktionella material, FNM
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Johansson, Sara M. (author)
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Ahlborg, Niklas (author)
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- Muhammed, Mamoun A. (author)
- KTH,Funktionella material, FNM
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- Scheynius, Annika (author)
- Karolinska Institutet
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- Gabrielsson, Susanne (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2006-07-22
- 2006
- English.
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In: Nano letters (Print). - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 6:8, s. 1682-1686
- Related links:
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http://pubs.acs.org/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We investigated the effect of spherical gold nanoparticles on immature dendritic cells (DCs). Conventionally produced nanoparticles had a maturating effect on the DCs-a result of lipopolysaccharide (LPS) contamination. By modification of the production process, low-LPS particles were obtained, which had practically no effect on phenotypic maturation or cytokine production of the DCs. Our findings emphasize the importance of high purity in the production of nanoparticles, since possible contaminants may interfere with the assessment of biological/medical effects. They also highlight that nanoparticles can function as carriers of immune modulating contaminants.
Subject headings
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
Keyword
- human dendritic cells
- gold
- immunity
- lipopolysaccharide
- contamination
- maturation
- particles
- receptor
- innate
- metal
- Materials chemistry
- Materialkemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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