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Direct STD NMR Iden...
Direct STD NMR Identification of beta-Galactosidase Inhibitors from a Virtual Dynamic Hemithioacetal System
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- Caraballo, Rémi (author)
- KTH,Organisk kemi
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- Dong, Hai (author)
- KTH,Organisk kemi
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Ribeiro, Joao P. (author)
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Jimenez-Barbero, Jesus (author)
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- Ramström, Olof (author)
- KTH,Organisk kemi
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(creator_code:org_t)
- 2009-12-10
- 2010
- English.
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In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 49:3, s. 589-593
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- The formation of a dynamic hemithioacetal system and its application toward the discovery of ß-galactosidase inhibitors were successfully investigated. The designed dynamic system, which has a virtual character in neutral aqueous media, was subjected to a direct in situ identification of the best inhibitors by 1H STD NMR spectroscopy (ONPC : o-nitrophenyl-β-galactopyranoside).
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- beta-galactosidase
- dynamic chemistry
- hemithioacetals
- inhibition
- NMR spectroscopy
- NUCLEAR-MAGNETIC-RESONANCE
- COMBINATORIAL LIBRARIES
- ESCHERICHIA-COLI
- LIGAND-BINDING
- LIVING CELLS
- ACTIVE-SITE
- CHEMISTRY
- SPECTROSCOPY
- RECEPTORS
- PROTEIN
- Chemistry
- Kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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