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Integration of card...
Integration of cardiac proteome biology and medicine by a specialized knowledgebase
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Zong, N. C. (author)
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Li, H. (author)
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Lam, M. P. Y. (author)
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Jimenez, R. C. (author)
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Kim, C. S. (author)
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Deng, N. (author)
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Kim, A. K. (author)
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Choi, J. H. (author)
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Zelaya, I. (author)
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Liem, D. (author)
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Meyer, D. (author)
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- Odeberg, Jacob (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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Fang, C. (author)
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Lu, H. -J (author)
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Xu, T. (author)
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Weiss, J. (author)
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Duan, H. (author)
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- Uhlén, Mathias (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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Yates III, J. R. (author)
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Apweiler, R. (author)
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Ge, J. (author)
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Hermjakob, H. (author)
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Ping, P. (author)
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(creator_code:org_t)
- 2013
- 2013
- English.
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In: Circulation Research. - 0009-7330 .- 1524-4571. ; 113:9, s. 1043-1053
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Rationale: Omics sciences enable a systems-level perspective in characterizing cardiovascular biology. Integration of diverse proteomics data via a computational strategy will catalyze the assembly of contextualized knowledge, foster discoveries through multidisciplinary investigations, and minimize unnecessary redundancy in research efforts. Objective: The goal of this project is to develop a consolidated cardiac proteome knowledgebase with novel bioinformatics pipeline and Web portals, thereby serving as a new resource to advance cardiovascular biology and medicine. Methods and results: We created Cardiac Organellar Protein Atlas Knowledgebase (COPaKB; www.HeartProteome.org), a centralized platform of high-quality cardiac proteomic data, bioinformatics tools, and relevant cardiovascular phenotypes. Currently, COPaKB features 8 organellar modules, comprising 4203 LC-MS/MS experiments from human, mouse, drosophila, and Caenorhabditis elegans, as well as expression images of 10 924 proteins in human myocardium. In addition, the Java-coded bioinformatics tools provided by COPaKB enable cardiovascular investigators in all disciplines to retrieve and analyze pertinent organellar protein properties of interest. Conclusions: COPaKB provides an innovative and interactive resource that connects research interests with the new biological discoveries in protein sciences. With an array of intuitive tools in this unified Web server, nonproteomics investigators can conveniently collaborate with proteomics specialists to dissect the molecular signatures of cardiovascular phenotypes.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Computational biology
- COPaKB
- Mitochondria
- Omics science
- Organelles
- Proteomics
- Translational medical research
- protein
- proteome
- article
- bioinformatics
- Caenorhabditis elegans
- cardiology
- Drosophila
- heart muscle
- human
- nonhuman
- phenotype
- priority journal
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Zong, N. C.
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Li, H.
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Lam, M. P. Y.
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Jimenez, R. C.
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Kim, C. S.
-
Deng, N.
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show more...
-
Kim, A. K.
-
Choi, J. H.
-
Zelaya, I.
-
Liem, D.
-
Meyer, D.
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Odeberg, Jacob
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Fang, C.
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Lu, H. -J
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Xu, T.
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Weiss, J.
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Duan, H.
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Uhlén, Mathias
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Yates III, J. R.
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Apweiler, R.
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Ge, J.
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Hermjakob, H.
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Ping, P.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Circulation Rese ...
- By the university
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Royal Institute of Technology