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Liposome and protei...
Liposome and protein based stealth nanoparticles
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Nogueira, Eugenia (author)
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Loureiro, Ana (author)
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Nogueira, Patricia (author)
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Freitas, Jaime (author)
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Almeida, Catarina R. (author)
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- Härmark, Johan (author)
- KTH,Strukturell bioteknik,Karolinska Institutet, Sweden
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- Hebert, Hans (author)
- KTH,Strukturell bioteknik,Karolinska Institutet, Sweden
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Moreira, Alexandra (author)
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Carmo, Alexandre M. (author)
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Preto, Ana (author)
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Gomes, Andreia C. (author)
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Cavaco-Paulo, Artur (author)
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(creator_code:org_t)
- Royal Society of Chemistry (RSC), 2013
- 2013
- English.
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In: Faraday discussions. - : Royal Society of Chemistry (RSC). - 1359-6640 .- 1364-5498. ; 166, s. 417-429
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Liposomes and protein based nanoparticles were tuned with different polymers and glycolipids to improve stealth and thus decrease their clearance by macrophages. Liposomes were coated with polyethylene glycol (PEG) and brain-tissue-derived monosialoganglioside (GM1). Bovine serum albumin (BSA) nanoparticles were produced incorporating a PEGylated surfactant (PEG-surfactant). All obtained nanoparticles were monodisperse, with sizes ranging from 80 to 120 nm, with a zeta-potential close to zero. The presented stealth strategies lead to a decrease of internalization levels by macrophages. These surface modified nanoparticles could be used for production of new drug delivery nanosystems for systemic administration (e.g. intravenous application).
Subject headings
- NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Drug-Delivery Systems
- Poly(Ethylene Glycol)
- Circulation Time
- In-Vivo
- Cancer
- Opsonization
- Pharmacokinetics
- Microspheres
- Optimization
- Formulations
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nogueira, Eugeni ...
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Loureiro, Ana
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Nogueira, Patric ...
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Freitas, Jaime
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Almeida, Catarin ...
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Härmark, Johan
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show more...
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Hebert, Hans
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Moreira, Alexand ...
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Carmo, Alexandre ...
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Preto, Ana
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Gomes, Andreia C ...
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Cavaco-Paulo, Ar ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Other Chemistry ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Faraday discussi ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet