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MRI manifestation o...
MRI manifestation of novel superparamagnetic iron oxide nanoparticles in the rat inner ear
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- Zhou, Jing (author)
- University of Tampere
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- Zhang, Weikai (author)
- University of Tampere
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- Poe, Dennis (author)
- University of Tampere
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- Qin, Jian (author)
- KTH,Funktionella material, FNM
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- Fornara, Andrea (author)
- KTH,Funktionella material, FNM
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- Zhang, Ya (author)
- University of Tampere
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- Ramadan, Usama (author)
- University of Helsinki
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- Muhammed, Mamoun (author)
- KTH,Funktionella material, FNM
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- Pyykkö, Ilmari (author)
- University of Tampere
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(creator_code:org_t)
- Future Medicine Ltd, 2010
- 2010
- English.
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In: Nanomedicine. - : Future Medicine Ltd. - 1743-5889 .- 1748-6963. ; 5:5, s. 739-754
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Aim: Superparamagnetic iron oxide nanoparticles hierarchically coated with oleic acid and Pluronic F127 copolymers (POA@SPION) have shown exceptional 12 contrast enhancement. The aim of the present work was to investigate the MRI manifestation of POA@SPION in the inner ear. Materials & methods: A total of 26 male Wister rats were selected for testing POA@SPION administered through intracochlear, intratympanic and intravenous routes. MRI was performed with a 4.7 T MR scanner. Results & conclusion: POA@SPION can be introduced into the perilymph space, after which it becomes widely distributed and can demonstrate the integrity of the perilymph-endolymph barrier. Positive highlighting of the endolymph compartment against the darkened perilymph was visualized for the first time. POA@SPION passed through the middle-inner ear barriers in only small amounts, but stayed in the perilymph for 3 days. They did not traverse the blood-perilymph barrier or blood-endolymph barrier. The inner ear distribution of POA@SPION was confirmed by histology. POA@SPION is a promising T2 negative contrast agent.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
Keyword
- animal
- biological barrier
- biomaterial
- contrast agent inner ear fluids
- MRI
- nanoparticle
- superparamagnetic iron oxide nanoparticles
- tight junction
- Medical engineering
- Medicinsk teknik
Publication and Content Type
- ref (subject category)
- art (subject category)
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