onr:"swepub:oai:DiVA.org:kth-143348"
Search: onr:"swepub:oai:DiVA.org:kth-143348" > Real-time study of ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Real-time study of shape and thermal fluctuations in the echinocyte transformation of human erythrocytes using defocusing microscopy
-
- Etcheverry, Sebastián (author)
- Universidad de Concepción, Chile
- Gallado, Maria Jose (author)
- Solano, Pablo (author)
- show more...
- Suwalsky, Mario (author)
- Mesquita, Oscar (author)
- Saavedra, Carlos (author)
- show less...
- (creator_code:org_t)
- 2012
- 2012
- English.
- In: Journal of Biomedical Optics. - 1083-3668 .- 1560-2281. ; 17:10, s. 106013-
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- We present a real-time method to measure the amplitude of thermal fluctuations in biological membranes by means of a new treatment of the defocusing microscopy (DM) optical technique. This approach was also applied to study the deformation of human erythrocytes to its echinocyte structure. This was carried out by making three-dimensional shape reconstructions of the cell and measuring the thermal fluctuations of its membrane, as the cell is exposed to the anti-inflammatory drug naproxen and as it recovers its original shape, when it is subsequently cleansed of the drug. The results showed biomechanical changes in the membrane even at low naproxen concentration (0.2 mM). Also, we found that when the cell recovered its original shape, the membrane properties were different compared to the nondrugged initial erythrocyte, indicating that the drug administration-recovery process is not completely reversible.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- red blood cells
- erythrocyte
- membrane dynamics
- bright field microscopy
- Biological Physics
- Biologisk fysik
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Journal of Biomedical Optics (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Etcheverry, Seba ...
- Gallado, Maria J ...
- Solano, Pablo
- Suwalsky, Mario
- Mesquita, Oscar
- Saavedra, Carlos
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Biochemistry and ...
- Articles in the publication
- Journal of Biome ...
- By the university
- Royal Institute of Technology
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
