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  • Kalderén, ChristinaKarolinska Institutet (author)

CCL2 mediates anti-fibrotic effects in human fibroblasts independently of CCR2

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • Elsevier BV,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-147051
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-147051URI
  • https://doi.org/10.1016/j.intimp.2014.02.020DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:129043745URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20140624
  • CCL2 is known for its major role as a chemoattractant of monocytes for immunological surveillance and to site of inflammation. CCL2 acts mainly through the G-protein-coupled receptor CCR2 but has also been described to mediate its effects independently of this receptor in vitro and in vivo. Emerging pieces of evidence indicate that the CCL2/CCR2 axis is involved in fibrotic diseases, such as increased plasma levels of CCL2 and the presence of CCL2-hyperresponsive fibroblasts explanted from patients with systemic sclerosis and idiopathic pulmonary fibrosis. One of the profibrotic key mediators is the myofibroblast characterized by overexpression of alpha-smooth muscle actin and collagen I. However, the correlation between the CCL2/CCR2 axis and the activation of fibroblasts is not yet fully understood. We have screened human fibroblasts of various origins, human pulmonary fibroblasts (HPF), human fetal lung fibroblasts (HFL-1) and primary preadipocytes (SPF-1) in regard to CCL2 stimulated fibrotic responses. Surprisingly we found that CCL2 mediates anti-fibrotic effects independently of CCR2 in human fibroblasts of different origins.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Stadler, CharlotteKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1r100ik (author)
  • Forsgren, Margareta (author)
  • Kvastad, LindaKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1fok912 (author)
  • Johansson, ElinKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u151qhvp (author)
  • Sydow-Bäckman, Mona (author)
  • Gelius, Stefan Svensson (author)
  • Karolinska InstitutetProteomik och nanobioteknologi (creator_code:org_t)

Related titles

  • In:International Immunopharmacology: Elsevier BV20:1, s. 66-731567-57691878-1705

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