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CCL2 mediates anti-...
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Kalderén, ChristinaKarolinska Institutet
(author)
CCL2 mediates anti-fibrotic effects in human fibroblasts independently of CCR2
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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Elsevier BV,2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-147051
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-147051URI
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https://doi.org/10.1016/j.intimp.2014.02.020DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:129043745URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20140624
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CCL2 is known for its major role as a chemoattractant of monocytes for immunological surveillance and to site of inflammation. CCL2 acts mainly through the G-protein-coupled receptor CCR2 but has also been described to mediate its effects independently of this receptor in vitro and in vivo. Emerging pieces of evidence indicate that the CCL2/CCR2 axis is involved in fibrotic diseases, such as increased plasma levels of CCL2 and the presence of CCL2-hyperresponsive fibroblasts explanted from patients with systemic sclerosis and idiopathic pulmonary fibrosis. One of the profibrotic key mediators is the myofibroblast characterized by overexpression of alpha-smooth muscle actin and collagen I. However, the correlation between the CCL2/CCR2 axis and the activation of fibroblasts is not yet fully understood. We have screened human fibroblasts of various origins, human pulmonary fibroblasts (HPF), human fetal lung fibroblasts (HFL-1) and primary preadipocytes (SPF-1) in regard to CCL2 stimulated fibrotic responses. Surprisingly we found that CCL2 mediates anti-fibrotic effects independently of CCR2 in human fibroblasts of different origins.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Stadler, CharlotteKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1r100ik
(author)
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Forsgren, Margareta
(author)
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Kvastad, LindaKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1fok912
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Johansson, ElinKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u151qhvp
(author)
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Sydow-Bäckman, Mona
(author)
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Gelius, Stefan Svensson
(author)
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Karolinska InstitutetProteomik och nanobioteknologi
(creator_code:org_t)
Related titles
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In:International Immunopharmacology: Elsevier BV20:1, s. 66-731567-57691878-1705
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