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Influence of corona...
Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism
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- Bruzelius, Maria (author)
- Karolinska Institutet
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- Strawbridge, Rona J. (author)
- Karolinska Institutet
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Tregouet, David-Alexandre (author)
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Wiggins, Kerri L. (author)
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- Gertow, Karl (author)
- Karolinska Institutet
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- Sabater-Lleal, Maria (author)
- Karolinska Institutet
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- Ohrvik, John (author)
- Karolinska Institutet
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Bergendal, Annica (author)
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- Silveira, Angela (author)
- Karolinska Institutet
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- Sundström, Anders (author)
- Karolinska Institutet
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- Kieler, Helle (author)
- Karolinska Institutet
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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Smith, Nicholas L. (author)
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Morange, Pierre-Emmanuel (author)
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- Odeberg, Jacob (author)
- Karolinska Institutet,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,Coagulation Unit, Hematology Centre; Atherosclerosis Research Unit, Centre for Molecular Medicine Karolinska University Hospital Solna, Sweden
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- Hamsten, Anders (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Thrombosis Research. - : Elsevier BV. - 0049-3848 .- 1879-2472. ; 134:2, s. 426-432
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Introduction: We investigated whether genetic variations robustly associated with coronary artery disease are also associated with risk of venous thromboembolism in a well-defined, female case-control study (n = 2753) from Sweden. Materials and Methods: 39 single nucleotide polymorphisms in 32 loci associated with coronary artery disease in genome-wide association studies were identified in a literature search and genotyped in the ThromboEmbolism Hormone Study (TEHS). Association with venous thromboembolism was assessed by logistic regression. Results: Only rs579459 in the ABO locus demonstrated a significant association with VTE. A tentative association between ANRIL and VTE in the discovery analysis failed to replicate in a meta-analysis of 4 independent cohorts (total n = 7181). Conclusions: It appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Venous thromboembolism
- Coronary artery disease
- ANRIL
- ABO
- Genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bruzelius, Maria
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Strawbridge, Ron ...
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Tregouet, David- ...
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Wiggins, Kerri L ...
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Gertow, Karl
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Sabater-Lleal, M ...
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show more...
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Ohrvik, John
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Bergendal, Annic ...
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Silveira, Angela
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Sundström, Ander ...
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Kieler, Helle
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Syvänen, Ann-Chr ...
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Smith, Nicholas ...
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Morange, Pierre- ...
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Odeberg, Jacob
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Hamsten, Anders
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Thrombosis Resea ...
- By the university
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Royal Institute of Technology
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Uppsala University
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Karolinska Institutet