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Inter-laboratory validation of bioaccessibility testing for metals
- Henderson, Rayetta G. (author)
- Verougstraete, Violaine (author)
- Anderson, Kim (author)
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- Arbildua, Jose J. (author)
- Brock, Thomas O. (author)
- Brouwers, Tony (author)
- Cappellini, Danielle (author)
- Delbeke, Katrien (author)
- Hixon, Greg (author)
- Rodriguez, Patricio H. (author)
- Van Assche, Frank (author)
- Wilrich, Peter (author)
- Oller, Adriana R. (author)
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- (creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
- In: Regulatory toxicology and pharmacology. - : Elsevier BV. - 0273-2300 .- 1096-0295. ; 70:1, s. 170-181
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Bioelution assays are fast, simple alternatives to in vivo testing. In this study, the intra- and inter-laboratory variability in bioaccessibility data generated by bioelution tests were evaluated in synthetic fluids relevant to oral, inhalation, and dermal exposure. Using one defined protocol, five laboratories measured metal release from cobalt oxide, cobalt powder, copper concentrate, Inconel alloy, leaded brass alloy, and nickel sulfate hexahydrate. Standard deviations of repeatability (S-r) and reproducibility (S-R) were used to evaluate the intra- and inter-laboratory variability, respectively. Examination of the s(R):s(r) ratios demonstrated that, while gastric and lysosomal fluids had reasonably good reproducibility, other fluids did not show as good concordance between laboratories. Relative standard deviation (RSD) analysis showed more favorable reproducibility outcomes for some data sets; overall results varied more between- than within-laboratories. RSD analysis of s(r) showed good within-laboratory variability for all conditions except some metals in interstitial fluid. In general, these findings indicate that absolute bioaccessibility results in some biological fluids may vary between different laboratories. However, for most applications, measures of relative bioaccessibility are needed, diminishing the requirement for high inter-laboratory reproducibility in absolute metal releases. The inter-laboratory exercise suggests that the degrees of freedom within the protocol need to be addressed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Metals
- Alloys
- UVCBs
- Classification
- Bioelution
- Bioaccessibility
- Read-across
- Inter-laboratory validation
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- ref (subject category)
- art (subject category)
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