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Affinity Proteomics...
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Bachmann, JulieKTH,Science for Life Laboratory, SciLifeLab
(author)
Affinity Proteomics Reveals Elevated Muscle Proteins in Plasma of Children with Cerebral Malaria
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-04-17
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Public Library of Science (PLoS),2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-155155
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-155155URI
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https://doi.org/10.1371/journal.ppat.1004038DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:129853037URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235651URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20141103
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Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria complications than others. To identify human proteins in plasma related to childhood malaria syndromes, multiplex antibody suspension bead arrays were employed. Out of the 1,015 proteins analyzed in plasma from more than 700 children, 41 differed between malaria infected children and community controls, whereas 13 discriminated uncomplicated malaria from severe malaria syndromes. Markers of oxidative stress were found related to severe malaria anemia while markers of endothelial activation, platelet adhesion and muscular damage were identified in relation to children with cerebral malaria. These findings suggest the presence of generalized vascular inflammation, vascular wall modulations, activation of endothelium and unbalanced glucose metabolism in severe malaria. The increased levels of specific muscle proteins in plasma implicate potential muscle damage and microvasculature lesions during the course of cerebral malaria.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Burte, Florence
(author)
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Pramana, Setia
(author)
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Conte, Ianina
(author)
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Brown, Biobele J.
(author)
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Orimadegun, Adebola E.
(author)
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Ajetunmobi, Wasiu A.
(author)
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Afolabi, Nathaniel K.
(author)
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Akinkunmi, Francis
(author)
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Omokhodion, Samuel
(author)
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Akinbami, Felix O.
(author)
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Shokunbi, Wuraola A.
(author)
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Kampf, CarolineUppsala universitet,Molekylär och morfologisk patologi(Swepub:uu)carokamp
(author)
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Pawitan, YudiKarolinska Institutet
(author)
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Uhlén, MathiasKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1dulvmw
(author)
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Sodeinde, Olugbemiro
(author)
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Schwenk, Jochen M.KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1h7wtme
(author)
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Wahlgren, MatsKarolinska Institutet
(author)
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Fernandez-Reyes, Delmiro
(author)
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Nilsson, PeterKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1ws88sk
(author)
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KTHScience for Life Laboratory, SciLifeLab
(creator_code:org_t)
Related titles
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In:PLoS Pathogens: Public Library of Science (PLoS)10:4, s. e1004038-1553-73661553-7374
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Bachmann, Julie
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Burte, Florence
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Pramana, Setia
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Conte, Ianina
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Brown, Biobele J ...
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Orimadegun, Adeb ...
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Ajetunmobi, Wasi ...
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Afolabi, Nathani ...
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Akinkunmi, Franc ...
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Omokhodion, Samu ...
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Akinbami, Felix ...
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Shokunbi, Wuraol ...
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Kampf, Caroline
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Pawitan, Yudi
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Uhlén, Mathias
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Sodeinde, Olugbe ...
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Schwenk, Jochen ...
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Wahlgren, Mats
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Fernandez-Reyes, ...
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Nilsson, Peter
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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PLoS Pathogens
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Royal Institute of Technology
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Karolinska Institutet
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Uppsala University