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Magnetic resonance tracking of nanoparticle labelled neural stem cells in a rat's spinal cord
- Wang, F. H. (author)
- Lee, I. H. (author)
-
- Holmstrom, N. (author)
- Karolinska Institutet
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- Kim, D. K. (author)
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- (creator_code:org_t)
- 2006-03-15
- 2006
- English.
- In: Nanotechnology. - : IOP Publishing. - 0957-4484 .- 1361-6528. ; 17:8, s. 1911-1915
- Journal article (peer-reviewed)
Abstract
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- Neural stem cells isolated from an adult rat's spinal cord were loaded with superparamagnetic gold-coated monocrystalline iron oxide nanoparticles (Au-MION) intended for use as contrast enhancers in magnetic resonance imaging (MRI). A dose-dependent attenuation of MRI signals was observed for Au-MION down to 0.001 mu gFe/mu l and for nanoparticle-loaded clusters of only 20 cells. The labelled cells were infused into the spinal cord of anaesthetized rats and tracked by MRI at 1 h, 48 h and 1 month post-injection. Histological analysis revealed that MRI signals correlated well with gold-positive staining of transplanted cells. The present results show that Au-MION exerts powerful contrast-enhancing properties and may represent novel MRI labels for labelling and tracking the transplanted cells in vivo.
Keyword
- superparamagnetic iron-oxide
- in-vivo tracking
- contrast agents
- radicals
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- art (subject category)
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- Wang, F. H.
- Lee, I. H.
- Holmstrom, N.
- Yoshitake, T.
- Kim, D. K.
- Muhammed, Mamoun
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- Frisen, J.
- Olson, L.
- Spenger, C.
- Kehr, J.
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- Nanotechnology
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- Royal Institute of Technology
- Karolinska Institutet
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