onr:"swepub:oai:DiVA.org:kth-15701"
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- Wang, F. H. (author)
Magnetic resonance tracking of nanoparticle labelled neural stem cells in a rat's spinal cord
- Article/chapterEnglish2006
Publisher, publication year, extent ...
- 2006-03-15
- IOP Publishing,2006
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-15701
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-15701URI
- https://doi.org/10.1088/0957-4484/17/8/018DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1944962URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- QC 20100525
- Neural stem cells isolated from an adult rat's spinal cord were loaded with superparamagnetic gold-coated monocrystalline iron oxide nanoparticles (Au-MION) intended for use as contrast enhancers in magnetic resonance imaging (MRI). A dose-dependent attenuation of MRI signals was observed for Au-MION down to 0.001 mu gFe/mu l and for nanoparticle-loaded clusters of only 20 cells. The labelled cells were infused into the spinal cord of anaesthetized rats and tracked by MRI at 1 h, 48 h and 1 month post-injection. Histological analysis revealed that MRI signals correlated well with gold-positive staining of transplanted cells. The present results show that Au-MION exerts powerful contrast-enhancing properties and may represent novel MRI labels for labelling and tracking the transplanted cells in vivo.
Subject headings and genre
- superparamagnetic iron-oxide
- in-vivo tracking
- contrast agents
- radicals
Added entries (persons, corporate bodies, meetings, titles ...)
- Lee, I. H. (author)
- Holmstrom, N.Karolinska Institutet (author)
- Yoshitake, T.Karolinska Institutet (author)
- Kim, D. K. (author)
- Muhammed, MamounKTH,Materialvetenskap(Swepub:kth)u1m5r8td (author)
- Frisen, J.Karolinska Institutet (author)
- Olson, L.Karolinska Institutet (author)
- Spenger, C.Karolinska Institutet (author)
- Kehr, J.Karolinska Institutet (author)
- Karolinska InstitutetMaterialvetenskap (creator_code:org_t)
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- In:Nanotechnology: IOP Publishing17:8, s. 1911-19150957-44841361-6528
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- Wang, F. H.
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- Frisen, J.
- Olson, L.
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