Separate and combined effects of 21-day bed rest and hypoxic confinement on body composition

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Debevec, Tadej (author)

Separate and combined effects of 21-day bed rest and hypoxic confinement on body composition

Article/chapterEnglish2014

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2014-08-05
Springer Science and Business Media LLC,2014
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LIBRIS-ID:oai:DiVA.org:kth-157011
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-157011URI
https://doi.org/10.1007/s00421-014-2963-1DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

Notes

QC 20141205
This study tested the hypothesis that hypoxia exacerbates reductions in body mass observed during unloading. To discern the separate and combined effects of simulated microgravity and hypoxia, 11 healthy males underwent three 21-day campaigns in a counterbalanced fashion: (1) normoxic bed rest (NBR; FiO2 = 0.209; PiO2 = 133.1 +/- A 0.3); (2) hypoxic ambulatory confinement (HAMB; FiO2 = 0.141 +/- A 0.004; PiO2 = 90.0 +/- A 0.4; similar to 4,000 m); and (3) hypoxic bed rest (HBR; FiO2 = 0.141 +/- A 0.004; PiO2 = 90.0 +/- A 0.4). The same dietary menu was applied in all campaigns. Targeted energy intakes were estimated individually using the Harris-Benedict equation taking into account whether the subjects were bedridden or ambulatory. Body mass and water balance were assessed throughout the campaigns. Whole body and regional body composition was determined before and after the campaigns using dual-energy X-ray absorptiometry. Before and during the campaigns, indirect calorimetry and visual analogue scores were employed to assess the resting energy expenditure (REE) and perceived appetite sensations, respectively. Energy intakes were lower than targeted in all campaigns (NBR: -5 %; HAMB: -14 %; HBR: -6 %; P < 0.01). Body mass significantly decreased following all campaigns (NBR: -3 %; HAMB: -4 %; HBR: -5 %; P < 0.01). While fat mass was not significantly altered, the whole body fat free mass was reduced (NBR: -4 %; HAMB: -5 %; HBR: -5 %; P < 0.01), secondary to lower limb fat-free mass reduction. Water balance was comparable between the campaigns. No changes were observed in REE and perceived appetite. Exposure to simulated altitude of similar to 4,000 m does not seem to worsen the whole body mass and fat-free mass reductions or alter resting energy expenditure and appetite during a 21-day simulated microgravity.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
Normobaric hypoxia
Simulated microgravity
Fat-free mass
Energy expenditure
Appetite

Added entries (persons, corporate bodies, meetings, titles ...)

Bali, Tarsi C. (author)
Simpson, Elizabeth J. (author)
Macdonald, Ian A. (author)
Eiken, OlaKTH,Omgivningsfysiologi,Centrum för flyg- och rymdfysiologi, SAPC(Swepub:kth)u1fcwvxl (author)
Mekjavic, Igor B. (author)
KTHOmgivningsfysiologi (creator_code:org_t)

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In:European Journal of Applied Physiology: Springer Science and Business Media LLC114:11, s. 2411-24251439-63191439-6327

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