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Nano-Stereocomplexation of Polylactide (PLA) Spheres by Spray Droplet Atomization
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- Arias, Veluska (author)
- KTH,Fiber- och polymerteknologi
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- Odelius, Karin (author)
- KTH,Fiber- och polymerteknologi
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- Albertsson, Ann-Christine (author)
- KTH,Fiber- och polymerteknologi
- (creator_code:org_t)
- 2014-09-29
- 2014
- English.
- In: Macromolecular rapid communications. - : Wiley. - 1022-1336 .- 1521-3927. ; 35:22, s. 1949-1953
- Journal article (peer-reviewed)
Abstract
Subject headings
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- A direct, efficient, and scalable method to prepare stereocomplexed polylactide (PLA)-based nanoparticles (NPs) is achieved. By an appropriate combination of fabrication parameters, NPs with controlled shape and crystalline morphology are obtained and even pure PLA stereocomplexes (PLASC) are successfully prepared using the spray-drying technology. The formed particles of varying D- and L-LA content have an average size of approximate to 400 nm, where the smallest size is obtained for PLA50, which has an equimolar composition of PLLA and PDLA in solution. Raman spectra of the particles show the typical shifts for PLASC in PLA50, and thermal analysis indicates the presence of pure stereocomplexation, with only one melting peak at 226 degrees C. Topographic images of the particles exhibit a single phase with different surface roughness in correlation with the thermal analysis. A high yield of spherically shaped particles is obtained. The results clearly provide a proficient method for achieving PLASC NPs that are expected to function as renewable materials in PLA-based nanocomposites and potentially as more stable drug delivery carriers.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Polymerteknologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Polymer Technologies (hsv//eng)
Keyword
- biodegradable
- nanoparticles
- polylactides
- spray-drying
- stereocomplexes
Publication and Content Type
- ref (subject category)
- art (subject category)
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