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Impact of ABCB1 sin...
Impact of ABCB1 single nucleotide polymorphisms 1236C>T and 2677G>T on overall survival in FLT3 wild-type de novo AML patients with normal karyotype
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- Jakobsen Falk, Ingrid (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet
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- Fyrberg, Anna (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet
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- Paul, Esbjorn (author)
- Karolinska Institute, Sweden
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- Nahi, Hareth (author)
- Karolinska Institutet
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- Hermanson, Monica (author)
- Uppsala universitet,Medicinsk genetik
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- Rosenquist, Richard Brandell (author)
- Uppsala universitet,Hematologi och immunologi
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi
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- Palmqvist, Lars, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg, Sweden
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- Stockelberg, Dick, 1950 (author)
- Sahlgrens University Hospital, Sweden
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- Wei, Yuan, 1978 (author)
- Sahlgrens University Hospital, Sweden
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- Gréen, Henrik (author)
- Linköpings universitet,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Avdelningen för läkemedelsforskning,Hälsouniversitetet,KTH Royal Institute Technology, Sweden
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- Lotfi, Kourosh (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,Klinisk farmakologi
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(creator_code:org_t)
- 2014-08-23
- 2014
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 167:5, s. 671-680
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Abstract
Subject headings
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- Drug resistance is a clinically relevant problem in the treatment of acute myeloid leukaemia (AML). We have previously reported a relationship between single nucleotide polymorphisms (SNPs) of ABCB1, encoding the multi-drug transporter P-glycoprotein, and overall survival (OS) in normal karyotype (NK)-AML. Here we extended this material, enabling subgroup analysis based on FLT3 and NPM1 status, to further elucidate the influence of ABCB1 SNPs. De novo NK-AML patients (n = 201) were analysed for 1199G>A, 1236C>T, 2677G>T/A and 3435C>T, and correlations to outcome were investigated. FLT3 wild-type 1236C/C patients have significantly shorter OS compared to patients carrying the variant allele; medians 20 vs. 49 months, respectively, P = 0.017. There was also an inferior outcome in FLT3 wild-type 2677G/G patients compared to patients carrying the variant allele, median OS 20 vs. 35 months, respectively, P = 0.039. This was confirmed in Cox regression analysis. Our results indicate that ABCB1 1236C>T and 2677G>T may be used as prognostic markers to distinguish relatively high risk patients in the intermediate risk FLT3 wild-type group, which may contribute to future individualizing of treatment strategies.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- acute myeloid leukaemia
- ABCB1
- single nucleotide polymorphism
- anthracyclines
- FLT3
- ABCB1; FLT3; acute myeloid leukaemia; anthracyclines; single nucleotide polymorphism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jakobsen Falk, I ...
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Fyrberg, Anna
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Paul, Esbjorn
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Nahi, Hareth
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Hermanson, Monic ...
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Rosenquist, Rich ...
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show more...
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Höglund, Martin
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Palmqvist, Lars, ...
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Stockelberg, Dic ...
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Wei, Yuan, 1978
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Gréen, Henrik
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Lotfi, Kourosh
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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British Journal ...
- By the university
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Royal Institute of Technology
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University of Gothenburg
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Linköping University
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Karolinska Institutet
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Uppsala University