Search: onr:"swepub:oai:DiVA.org:kth-158941" > Plasma profiling re...
Fältnamn | Indikatorer | Metadata |
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000 | 04146naa a2200445 4500 | |
001 | oai:DiVA.org:kth-158941 | |
003 | SwePub | |
008 | 150115s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1589412 URI |
024 | 7 | a https://doi.org/10.1002/acn3.832 DOI |
040 | a (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Häggmark, Annau KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1g5roxd |
245 | 1 0 | a Plasma profiling revelas three proteins associated to amyotrophic lateral sclerosis |
264 | c 2014-07-14 | |
264 | 1 | b Wiley,c 2014 |
338 | a electronic2 rdacarrier | |
500 | a QC 20150115 | |
520 | a OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is the most common adult motor neuron disease leading to muscular paralysis and death within 3-5 years from onset. Currently, there are no reliable and sensitive markers able to substantially shorten the diagnosis delay. The objective of the study was to analyze a large number of proteins in plasma from patients with various clinical phenotypes of ALS in search for novel proteins or protein profiles that could serve as potential indicators of disease.METHODS: Affinity proteomics in the form of antibody suspension bead arrays were applied to profile plasma samples from 367 ALS patients and 101 controls. The plasma protein content was directly labeled and protein profiles obtained using 352 antibodies from the Human Protein Atlas targeting 278 proteins. A focused bead array was then built to further profile eight selected protein targets in all available samples.RESULTS: Disease-associated significant differences were observed and replicated for profiles from antibodies targeting the proteins: neurofilament medium polypeptide (NEFM), solute carrier family 25 (SLC25A20), and regulator of G-protein signaling 18 (RGS18).INTERPRETATION: Upon further validation in several independent cohorts with inclusion of a broad range of other neurological disorders as controls, the alterations of these three protein profiles in plasma could potentially provide new molecular markers of disease that contribute to the quest of understanding ALS pathology. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomedicinsk laboratorievetenskap/teknologi0 (SwePub)304022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomedical Laboratory Science/Technology0 (SwePub)304022 hsv//eng |
700 | 1 | a Mikus, Mariau KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1qjoszn |
700 | 1 | a Mohsenchian, Atefehu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1nf4uzu |
700 | 1 | a Hong, Mun-Gwanu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u19gmsru |
700 | 1 | a Forsström, Björnu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u11i5nju |
700 | 1 | a Gajewska, Beata4 aut |
700 | 1 | a Baranczyk-Kuzma, Anna4 aut |
700 | 1 | a Uhlén, Mathiasu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1dulvmw |
700 | 1 | a Schwenk, Jochen M.u KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1h7wtme |
700 | 1 | a Kuzma-Kozakiewicz, Magdalena4 aut |
700 | 1 | a Nilsson, Peteru KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ws88sk |
710 | 2 | a KTHb Proteomik och nanobioteknologi4 org |
773 | 0 | t Annals of Clinical and Translational Neurologyd : Wileyg 1:8, s. 544-553q 1:8<544-553x 2328-9503 |
856 | 4 | u https://kth.diva-portal.org/smash/get/diva2:780956/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.83 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-158941 |
856 | 4 8 | u https://doi.org/10.1002/acn3.83 |
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