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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06333naa a2201057 4500 | |
| 001 | oai:DiVA.org:kth-160037 | |
| 003 | SwePub | |
| 008 | 150213s2014 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-235383 | |
| 009 | oai:prod.swepub.kib.ki.se:132238794 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1600372 URI |
| 024 | 7 | a https://doi.org/10.1016/j.ejmech.2014.09.0822 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2353832 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1322387942 URI |
| 040 | a (SwePub)kthd (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Altai, Mohamedu Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap,Tolmachev4 aut0 (Swepub:uu)mohal988 |
| 245 | 1 0 | a Selection of an optimal cysteine-containing peptide-based chelator for labeling of affibody molecules with (188)Re. |
| 264 | 1 | b Elsevier BV,c 2014 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20150213 | |
| 520 | a Affibody molecules constitute a class of small (7 kDa) scaffold proteins that can be engineered to have excellent tumor targeting properties. High reabsorption in kidneys complicates development of affibody molecules for radionuclide therapy. In this study, we evaluated the influence of the composition of cysteine-containing C-terminal peptide-based chelators on the biodistribution and renal retention of (188)Re-labeled anti-HER2 affibody molecules. Biodistribution of affibody molecules containing GGXC or GXGC peptide chelators (where X is G, S, E or K) was compared with biodistribution of a parental affibody molecule ZHER2:2395 having a KVDC peptide chelator. All constructs retained low picomolar affinity to HER2-expressing cells after labeling. The biodistribution of all (188)Re-labeled affibody molecules was in general comparable, with the main observed difference found in the uptake and retention of radioactivity in excretory organs. The (188)Re-ZHER2:V2 affibody molecule with a GGGC chelator provided the lowest uptake in all organs and tissues. The renal retention of (188)Re-ZHER2:V2 (3.1 ± 0.5 %ID/g at 4 h after injection) was 55-fold lower than retention of the parental (188)Re-ZHER2:2395 (172 ± 32 %ID/g). We show that engineering of cysteine-containing peptide-based chelators can be used for significant improvement of biodistribution of (188)Re-labeled scaffold proteins, particularly reduction of their uptake in excretory organs. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Övrig annan medicin och hälsovetenskap0 (SwePub)305992 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Other Medical and Health Sciences not elsewhere specified0 (SwePub)305992 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologi0 (SwePub)3042 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnology0 (SwePub)3042 hsv//eng |
| 653 | a Affibody | |
| 653 | a Affinity discrimination | |
| 653 | a Cell surface display | |
| 653 | a FACS | |
| 653 | a Gram positive | |
| 653 | a Staphylococcus carnosus | |
| 653 | a immunoglobulin G | |
| 653 | a membrane protein | |
| 653 | a antibody combining site | |
| 653 | a article | |
| 653 | a binding affinity | |
| 653 | a cell interaction | |
| 653 | a cellular distribution | |
| 653 | a evaluation | |
| 653 | a fluorescence activated cell sorting | |
| 653 | a nonhuman | |
| 653 | a priority journal | |
| 653 | a protein domain | |
| 653 | a protein expression | |
| 653 | a protein localization | |
| 653 | a protein targeting | |
| 653 | a signal transduction | |
| 653 | a Staphylococcus | |
| 653 | a Staphylococcus carnosus | |
| 653 | a surface property | |
| 653 | a Amino Acid Sequence | |
| 653 | a Antibody Affinity | |
| 653 | a Flow Cytometry | |
| 653 | a Immunoglobulin G | |
| 653 | a Molecular Sequence Data | |
| 653 | a Mutation | |
| 653 | a Peptide Library | |
| 653 | a Protein Structure | |
| 653 | a Tertiary | |
| 653 | a Recombinant Proteins | |
| 653 | a Sequence Alignment | |
| 653 | a Staphylococcal Protein A | |
| 653 | a Staphylococcus | |
| 653 | a Transformation | |
| 653 | a Bacterial | |
| 653 | a Posibacteria | |
| 653 | a Staphylococcus carnosus | |
| 700 | 1 | a Honarvar, Hadisu Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap,Tolmachev4 aut0 (Swepub:uu)hadho340 |
| 700 | 1 | a Wållberg, Helenau KTH,Proteinteknologi4 aut0 (Swepub:kth)u1527tt1 |
| 700 | 1 | a Strand, Joannau Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap,Tolmachev4 aut0 (Swepub:uu)joast981 |
| 700 | 1 | a Varasteh, Zohrehu Uppsala universitet,Plattformen för preklinisk PET,Orlova4 aut0 (Swepub:uu)zohva473 |
| 700 | 1 | a Rosestedt, Mariau Uppsala universitet,Plattformen för preklinisk PET,Orlova4 aut0 (Swepub:uu)marro433 |
| 700 | 1 | a Orlova, Annau Uppsala universitet,Plattformen för preklinisk PET4 aut0 (Swepub:uu)annaorlo |
| 700 | 1 | a Dunås, Finn4 aut |
| 700 | 1 | a Sandström, Mattiasu Uppsala universitet,Enheten för medicinsk strålfysik4 aut0 (Swepub:uu)masan637 |
| 700 | 1 | a Löfblom, Johnu KTH,Proteinteknologi4 aut0 (Swepub:kth)u1z7cgkl |
| 700 | 1 | a Tolmachev, Vladimiru Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap4 aut0 (Swepub:uu)vladtolm |
| 700 | 1 | a Ståhl, Stefanu KTH,Proteinteknologi4 aut0 (Swepub:kth)u1svy8i4 |
| 710 | 2 | a Uppsala universitetb Enheten för biomedicinsk strålningsvetenskap4 org |
| 773 | 0 | t European Journal of Medicinal Chemistryd : Elsevier BVg 87, s. 519-28q 87<519-28x 0223-5234x 1768-3254 |
| 856 | 4 | u https://doi.org/10.1016/j.ejmech.2014.09.082 |
| 856 | 4 | u https://doi.org/10.1016/j.ejmech.2014.09.082y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:759949/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-160037 |
| 856 | 4 8 | u https://doi.org/10.1016/j.ejmech.2014.09.082 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235383 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:132238794 |
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