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Bioinformatic analy...
Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications
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- Steffen-Munsberg, Fabian (author)
- KTH,Industriell bioteknologi,Greifswald University, Germany
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Vickers, Clare (author)
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Kohls, Hannes (author)
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- Land, Henrik (author)
- KTH,Industriell bioteknologi
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Mallin, Hendrik (author)
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Nobili, Alberto (author)
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Skalden, Lilly (author)
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van den Bergh, Tom (author)
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Joosten, Henk-Jan (author)
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- Berglund, Per (author)
- KTH,Industriell bioteknologi
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Höhne, Matthias (author)
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Bornscheuer, Uwe T. (author)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Biotechnology Advances. - : Elsevier BV. - 0734-9750 .- 1873-1899. ; 33:5, s. 566-604
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In this review we analyse structure/sequence-function relationships for the superfamily of PLP-dependent enzymes with special emphasis on class III transaminases. Amine transaminases are highly important for applications in biocatalysis in the synthesis of chiral amines. In addition, other enzyme activities such as racemases or decarboxylases are also discussed. The substrate scope and the ability to accept chemically different types of substrates are shown to be reflected in conserved patterns of amino acids around the active site. These findings are condensed in a sequence-function matrix, which facilitates annotation and identification of biocatalytically relevant enzymes and protein engineering thereof.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Annotation
- Biocatalysis
- Bioinformatics
- Enzyme discovery
- PLP-dependent enzymes
- Protein function
- Transaminase
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Steffen-Munsberg ...
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Vickers, Clare
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Kohls, Hannes
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Land, Henrik
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Mallin, Hendrik
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Nobili, Alberto
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show more...
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Skalden, Lilly
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van den Bergh, T ...
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Joosten, Henk-Ja ...
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Berglund, Per
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Höhne, Matthias
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Bornscheuer, Uwe ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Biotechnology Ad ...
- By the university
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Royal Institute of Technology