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- Bondesson, Maria (author)
Estrogen receptor signaling during vertebrate development
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- Elsevier BV,2015
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-165366
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-165366URI
- https://doi.org/10.1016/j.bbagrm.2014.06.005DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:130597913URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20150512
- Estrogen receptors are expressed and their cognate ligands produced in all vertebrates, indicative of important and conserved functions. Through evolution estrogen has been involved in controlling reproduction, affecting both the development of reproductive organs and reproductive behavior. This review broadly describes the synthesis of estrogens and the expression patterns of aromatase and the estrogen receptors, in relation to estrogen functions in the developing fetus and child. We focus on the role of estrogens for the development of reproductive tissues, as well as non-reproductive effects on the developing brain. We collate data from human, rodent, bird and fish studies and highlight common and species-specific effects of estrogen signaling on fetal development. Morphological malformations originating from perturbed estrogen signaling in estrogen receptor and aromatase knockout mice are discussed, as well as the clinical manifestations of rare estrogen receptor alpha and aromatase gene mutations in humans.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- Estrogen
- Aromatase
- Estrogen receptor
- Reproductive development
- Sex differentiation
- Vertebrate development
- SRA - Molecular Bioscience
- SRA - Molekylär biovetenskap
Added entries (persons, corporate bodies, meetings, titles ...)
- Hao, Ruixin (author)
- Lin, Chin-Yo (author)
- Williams, Cecilia,1969-University of Houston, United States(Swepub:kth)u1ygqmuy (author)
- Gustafsson, Jan-ÅkeKarolinska Institutet (author)
- Karolinska InstitutetUniversity of Houston, United States (creator_code:org_t)
Related titles
- In:Biochimica et Biophysica Acta. Gene Regulatory Mechanisms: Elsevier BV1849:2, s. 142-1511874-93991876-4320
- In:Biochimica et biophysica acta: Elsevier BV1849:2, s. 142-1510006-3002
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