Search: onr:"swepub:oai:DiVA.org:kth-16793" >
Neurotransmitter ph...
Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons
-
Apostolova, Galina (author)
-
Dorn, Roland (author)
-
- Ka, Sojeong (author)
- Uppsala universitet,Institutionen för neurovetenskap
-
show more...
-
- Hallböök, Finn (author)
- Uppsala universitet,Medicinsk utvecklingsbiologi
-
- Lundeberg, Joakim (author)
- KTH,Genteknologi
-
Liser, Keren (author)
-
Hakim, Vicky (author)
-
Brodski, Claude (author)
-
Michaelidis, Theologos M. (author)
-
Dechant, Georg (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
-
In: Molecular and Cellular Neuroscience. - : Elsevier BV. - 1044-7431 .- 1095-9327. ; 35:3, s. 397-408
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- During late developmental phases individual sympathetic neurons undergo a switch from noradrenergic to cholinergic neurotransmission. This phenomenon of plasticity depends on target-derived signals in vivo and is triggered by neurotrophic factors in neuronal cultures. To analyze genome-wide expression differences between the two transmitter phenotypes we employed DNA microarrays. RNA expression profiles were obtained from chick paravertebral sympathetic ganglia, treated with neurotrophin 3, glial cell line-derived neurotrophic factor or ciliary neurotrophic factor, all of which stimulate cholinergic differentiation. Results were compared with the effect of nerve growth factor, which functions as a pro-noradrenergic stimulus. The gene set common to all three comparisons defined the noradrenergic and cholinergic synexpression groups. Several functional categories, such as signal transduction, G-protein-coupled signaling, cation transport, neurogenesis and synaptic transmission, were enriched in these groups. Experiments based on the prediction that some of the identified genes play a role in the neurotransmitter switch identified bone morphogenetic protein signaling as an inhibitor of cholinergic differentiation.
Keyword
- acetylcholine
- noradrenalin
- sympathetic
- neurotrophic
- Microarray
- nerve growth-factor
- cholinergic differentiation
- neural crest
- in-vivo
- ganglia
- system
- induction
- cytokines
- pathways
- signals
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Apostolova, Gali ...
-
Dorn, Roland
-
Ka, Sojeong
-
Hallböök, Finn
-
Lundeberg, Joaki ...
-
Liser, Keren
-
show more...
-
Hakim, Vicky
-
Brodski, Claude
-
Michaelidis, The ...
-
Dechant, Georg
-
show less...
- Articles in the publication
-
Molecular and Ce ...
- By the university
-
Royal Institute of Technology
-
Uppsala University