Quest for Missing Proteins: Update 2015 on Chromosome-Centric Human Proteome Project

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Quest for Missing Proteins : Update 2015 on Chromosome-Centric Human Proteome Project

Horvatovich, Peter (author)

Lundberg, Emma K. (author): KTH,Science for Life Laboratory, SciLifeLab

Chen, Yu-Ju (author)

Sung, Ting-Yi (author)

He, Fuchu (author)

Nice, Edouard C. (author)

Goode, Robert J. (author)

Yu, Simon (author)

Ranganathan, Shoba (author)

Baker, Mark S. (author)

Domont, Gilberto B. (author)

Velasquez, Erika (author)

Li, Dong (author)

Liu, Siqi (author)

Wang, Quanhui (author)

He, Qing-Yu (author)

Menon, Rajasree (author)

Guan, Yuanfang (author)

Corrales, Fernando J. (author)

Segura, Victor (author)

Casal, J. Ignacio (author)

Pascual-Montano, Alberto (author)

Albar, Juan P. (author)

Fuentes, Manuel (author)

Gonzalez-Gonzalez, Maria (author)

Diez, Paula (author)

Ibarrola, Nieves (author)

Degano, Rosa M. (author)

Mohammed, Yassene (author)

Borchers, Christoph H. (author)

Urbani, Andrea (author)

Soggiu, Alessio (author)

Yamamoto, Tadashi (author)

Salekdeh, Ghasem Hosseini (author)

Archakov, Alexander (author)

Ponomarenko, Elena (author)

Lisitsa, Andrey (author)

Lichti, Cheryl F. (author)

Mostovenko, Ekaterina (author)

Kroes, Roger A. (author)

Rezeli, Melinda (author): Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH

Végvári, Ákos (author): Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH

Fehniger, Thomas (author): Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Department of Clinical Sciences, Lund,Faculty of Medicine

Bischoff, Rainer (author)

Vizcaino, Juan Antonio (author)

Deutsch, Eric W. (author)

Lane, Lydie (author)

Nilsson, Carol L. (author)

Marko-Varga, György (author): Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Department of Clinical Sciences, Lund,Faculty of Medicine

Omenn, Gilbert S. (author)

Jeong, Seul-Ki (author)

Lim, Jong-Sun (author)

Paik, Young-Ki (author)

Hancock, William S. (author)

Domont, Roberto (author)

Cho, Jin-Young (author)

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(creator_code:org_t)

2015-07-23
2015
English.
In: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 14:9, s. 3415-3431

Related links:: https://digital.csic...; show more...; http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; show less...

Journal article (other academic/artistic)

Abstract Subject headings

This paper summarizes the recent activities of the Chromosome-Centric Human Proteome Project (C-HPP) consortium, which develops new technologies to identify yet-to-be annotated proteins (termed "missing proteins") in biological samples that lack sufficient experimental evidence at the protein level for confident protein identification. The C-HPP also aims to identify new protein forms that may be caused by genetic variability, post-translational modifications, and alternative splicing. Proteogenomic data integration forms the basis of the C-HPP's activities; therefore, we have summarized some of the key approaches and their roles in the project. We present new analytical technologies that improve the chemical space and lower detection limits coupled to bioinformatics tools and some publicly available resources that can be used to improve data analysis or support the development of analytical assays. Most of this paper's content has been compiled from posters, slides, and discussions presented in the series of C-HPP workshops held during 2014. All data (posters, presentations) used are available at the C-HPP Wild (http://c-hpp.webhosting.rug.nl/) and in the Supporting Information.

Subject headings

NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Keyword

missing proteins
Chromosome-Centric Human Proteome Project
LC-MS
antibody enrichment
proteomics
bioinformatics
missing proteins
chromosome centric human proteome project
LC-MS
antibody enrichment
proteomics
bioinformatics

Publication and Content Type

vet (subject category)
art (subject category)

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By the author/editor: Horvatovich, Pet ...; Lundberg, Emma K ...; Chen, Yu-Ju; Sung, Ting-Yi; He, Fuchu; Nice, Edouard C.; show more...; Goode, Robert J.; Yu, Simon; Ranganathan, Sho ...; Baker, Mark S.; Domont, Gilberto ...; Velasquez, Erika; Li, Dong; Liu, Siqi; Wang, Quanhui; He, Qing-Yu; Menon, Rajasree; Guan, Yuanfang; Corrales, Fernan ...; Segura, Victor; Casal, J. Ignaci ...; Pascual-Montano, ...; Albar, Juan P.; Fuentes, Manuel; Gonzalez-Gonzale ...; Diez, Paula; Ibarrola, Nieves; Degano, Rosa M.; Mohammed, Yassen ...; Borchers, Christ ...; Urbani, Andrea; Soggiu, Alessio; Yamamoto, Tadash ...; Salekdeh, Ghasem ...; Archakov, Alexan ...; Ponomarenko, Ele ...; Lisitsa, Andrey; Lichti, Cheryl F ...; Mostovenko, Ekat ...; Kroes, Roger A.; Rezeli, Melinda; Végvári, Ákos; Fehniger, Thomas; Bischoff, Rainer; Vizcaino, Juan A ...; Deutsch, Eric W.; Lane, Lydie; Nilsson, Carol L ...; Marko-Varga, Gyö ...; Omenn, Gilbert S ...; Jeong, Seul-Ki; Lim, Jong-Sun; Paik, Young-Ki; Hancock, William ...; Domont, Roberto; Cho, Jin-Young; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Bioinformatics a ...

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

Articles in the publication: Journal of Prote ...

By the university: Royal Institute of Technology; Lund University

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