onr:"swepub:oai:DiVA.org:kth-176363"
Search: onr:"swepub:oai:DiVA.org:kth-176363" > Neuropeptide S- and...
- 1 of 1
- Previous record
- Next record
- To hitlist
Neuropeptide S- and Neuropeptide S receptor-expressing neuron populations in the human pons
-
- Adori, Csaba (author)
- Karolinska Institutet
-
- Barde, Swapnali (author)
- Karolinska Institutet
-
- Bogdanovic, Nenad (author)
- Karolinska Institutet
- show more...
- Reinscheid, Rainer R. (author)
- Kovacs, Gabor G. (author)
- show less...
- (creator_code:org_t)
- 2015-09-25
- 2015
- English.
- In: Frontiers in Neuroanatomy. - : Frontiers Media SA. - 1662-5129. ; 9
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Neuropeptide S (NPS) is a regulatory peptide with potent pharmacological effects. In rodents, NPS is expressed in a few pontine cell clusters. Its receptor (NPSR1) is, however, widely distributed in the brain. The anxiolytic and arousal promoting effects of NPS make the NPS NPSR1 system an interesting potential drug target in mood-related disorders. However, so far possible disease-related mechanisms involving NPS have only been studied in rodents. To validate the relevance of these animal studies for i.a. drug development, we have explored the distribution of NPS-expressing neurons in the human pons using in situ hybridization and stereological methods and we compared the distribution of NPS mRNA expressing neurons in the human and rat brain. The calculation revealed a total number of 22,317 +/- 2411 NPS mRNA-positive neurons in human, bilaterally. The majority of cells (84%) were located in the parabrachial area in human: in the extension of the medial and lateral parabrachial nuclei, in the Kolliker-Fuse nucleus and around the adjacent lateral lemniscus. In human, in sharp contrast to the rodents, only very few NPS-positive cells (5%) were found close to the locus coeruleus. In addition, we identified a smaller cell cluster (11% of all NPS cells) in the pontine central gray matter both in human and rat, which has not been described previously even in rodents. We also examined the distribution of NPSR1 mRNA-expressing neurons in the human pons. These cells were mainly located in the rostral laterodorsal tegmental nucleus, the cuneiform nucleus, the microcellular tegmental nucleus region and in the periaqueductal gray. Our results show that both NPS and NPSR1 in the human pons are preferentially localized in regions of importance for integration of visceral autonomic information and emotional behavior. The reported interspecies differences must, however, be considered when looking for targets for new pharmacotherapeutical interventions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Neuropeptide S (NPS)
- anxiety
- arousal
- deep brain stimulation (DBs)
- human brain
- parabrachial
- periaqueductal gray
- sudden infant death syndrome
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Frontiers in Neuroanatomy (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Adori, Csaba
- Barde, Swapnali
- Bogdanovic, Nena ...
- Uhlén, Mathias
- Reinscheid, Rain ...
- Kovacs, Gabor G.
- show more...
- Hokfelt, Tomas
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Frontiers in Neu ...
- By the university
- Royal Institute of Technology
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
