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Extremely Different...
Extremely Different Behaviours in High and Low Body Weight Lines of Chicken are Associated with Differential Expression of Genes Involved in Neuronal Plasticity
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- Ka, Sojeong, 1976- (author)
- Uppsala universitet,Medicinsk utvecklingsbiologi
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- Lindberg, Johan (author)
- KTH,Genteknologi
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- Strömstedt, Lina (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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Fitzsimmons, C. (author)
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- Lindqvist, N. (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Lundeberg, Joakim (author)
- KTH,Genteknologi
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Siegel, P. B. (author)
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- Andersson, Leif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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- Hallböök, Finn (author)
- Uppsala universitet,Medicinsk utvecklingsbiologi
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(creator_code:org_t)
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- Wiley, 2009
- 2009
- English.
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In: Journal of neuroendocrinology (Print). - : Wiley. - 0953-8194 .- 1365-2826 .- 0022-0795 .- 1479-6805. ; 21:3, s. 208-216
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Long-term selection (> 45 generations) for low or high body weight from the same founder population has generated two extremely divergent lines of chickens, the low (LWS) and high weight (HWS) lines, which at the age of selection (56 days) differs by more than nine-fold in body weight. The HWS line chickens are compulsive feeders, whereas, in the LWS line, some individuals are anorexic and others have very low appetites. The involvement of the central nervous system in these behavioural differences has been experimentally supported. We compared a brain region at 0 and 56 days of age containing the major metabolic regulatory regions, including the hypothalamus and brainstem, using a global cDNA array expression analysis. The results obtained show that the long-term selection has produced minor but multiple expression differences. Genes that regulate neuronal plasticity, such as actin filament polymerisation and brain-derived neurotrophic factor, were identified as being differentially expressed. Genes involved in lipid metabolism were over-represented among differentially expressed genes. The expression data confirm that neural systems regulating feeding behaviours in these lines are different. The results suggest that the lines are set in separate developmental trajectories equipped with slightly different nervous systems. We suggest that the lines adapt behaviourally different to changing situations post hatch, such as the transition from dependence on yolk to feeding, in order to obtain energy. The present study has identified and exemplifies the kind of changes that may underlie the extreme differences in such behaviours.
Subject headings
- LANTBRUKSVETENSKAPER -- Veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science (hsv//eng)
- LANTBRUKSVETENSKAPER -- Husdjursvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Animal and Dairy Sience (hsv//eng)
Keyword
- BDNF
- body weight
- cDNA microarray
- chicken
- feeding behaviour
- hypothalamus
- POMC
- selection lines
- single-nucleotide polymorphisms
- avian melanocortin system
- neurotrophic factor
- actin cytoskeleton
- red junglefowl
- severe
- obesity
- gland-function
- brain
- selection
- growth
- MEDICINE
- Developmental Neurosciences
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Ka, Sojeong, 197 ...
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Lindberg, Johan
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Strömstedt, Lina
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Fitzsimmons, C.
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Lindqvist, N.
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Lundeberg, Joaki ...
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show more...
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Siegel, P. B.
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Andersson, Leif
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Hallböök, Finn
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show less...
- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Veterinary Scien ...
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Animal and Dairy ...
- Articles in the publication
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Journal of neuro ...
- By the university
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Royal Institute of Technology
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Uppsala University
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Swedish University of Agricultural Sciences