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Structure and antin...
Structure and antinociceptive effects of beta-D-glucans from Cookeina tricholoma
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Moreno, Roberta B. (author)
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- Ruthes, Andrea Caroline (author)
- KTH,Glykovetenskap,Universidade Federal Do Paraná, Brazil
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Baggio, Cristiane H. (author)
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- Vilaplana, Francisco (author)
- KTH,Glykovetenskap
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Komura, Dirce L. (author)
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Iacomini, Marcello (author)
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(creator_code:org_t)
- Elsevier, 2016
- 2016
- English.
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In: Carbohydrate Polymers. - : Elsevier. - 0144-8617 .- 1879-1344. ; 141, s. 220-228
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Structurally different water-insoluble (1 -> 3),(1 -> 6) beta-D-glucans were isolated from aqueous and alkaline extracts of the mushroom-forming ascomycete Cookeina tricholoma, a wild edible mushroom found in Brazilian Amazon forest. The structures showed different substitution patterns, which may influence their extractability and consequently their conformation in solution, and different M-w (4.3 x 10(5) Da, 3.7 x 10(5) Da and 8.2 x 10(5) Da, for ICW-Ct, IHW-Ct and IK2-ct, respectively). The main-chains are composed of (1 -> 3) -linked beta-D-Glcp units 0-6 substituted by side chains with different lengths of (1 -> 6)-linked beta-D-Glcp units (ICW-Ct and IHW-Ct) or by a combination of (1 -> 6) -linked beta-D-Glcp units and single units of beta-D-Glcp (IK2-ct). beta-D-glucans with similar Mw and showing only (1 6) -linked beta-D-Glcp units as side chains (ICW-Ct and IHW-Ct) showed significant inhibition of neurogenic pain, 69 +/- 11 and 57 +/- 11% at the dose of 10 mg kg(-1), respectively, in the model of nociception induced by intraplantar injection of formalin.
Subject headings
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
Keyword
- Ascomycete Cookeina tricholoma
- (1 -> 3)
- (1 -> 6)-beta-D-Glucans
- Antinociceptive effect
Publication and Content Type
- ref (subject category)
- art (subject category)
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