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Estrogen receptor beta as target for colorectal cancer prevention
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- Williams, Cecilia (author)
- Karolinska Institutet,KTH,Skolan för bioteknologi (BIO),Science for Life Laboratory, SciLifeLab,University of Houston, USA; Karolinska Institutet, Sweden
- DiLeo, Alfredo (author)
- Niv, Yaron (author)
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- Gustafsson, Jan-Ake (author)
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- (creator_code:org_t)
- Elsevier, 2016
- 2016
- English.
- In: Cancer Letters. - : Elsevier. - 0304-3835 .- 1872-7980. ; 372:1, s. 48-56
- Research review (peer-reviewed)
Abstract
Subject headings
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- Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow development and the capacity for early diagnosis, current preventive approaches are not sufficient. However, a role for estrogen has been demonstrated in multiple epidemiologic studies, which may benefit CRC prevention. A large body of evidence from preclinical studies indicates that expression of the estrogen receptor beta (ER beta/ESR2) demonstrates an inverse relationship with the presence of colorectal polyps and stage of tumors, and can mediate a protective response. Natural compounds, including phytoestrogens, or synthetic ER beta selective agonists, can activate or upregulate ER beta in the colon and promote apoptosis in preclinical models and in clinical experience. Importantly, this activity has been associated with a reduction in polyp formation and, in rodent models of CRC, has been shown to lower incidence of colon adenocarcinoma. Collectively, these findings indicate that targeted activation of ER beta may represent a novel clinical approach for management of colorectal adenomatous polyps and prevention of colorectal carcinoma in patients at risk for this condition. In this review, we discuss the potential of new chemopreventive or dietary approaches based on estrogen signaling.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Colorectal cancer
- Estrogen
- Estrogen receptor beta
- Phytoestrogens
- Prevention
- Gene expression
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