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Live Cell Linear Di...
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Benninger, Richard K. P.
(author)
Live Cell Linear Dichroism Imaging Reveals Extensive Membrane Ruffling within the Docking Structure of Natural Killer Cell Immune Synapses
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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Elsevier BV,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-18450
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-18450URI
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https://doi.org/10.1016/j.bpj.2008.10.005DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:118814397URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20100525
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We have applied fluorescence imaging of two-photon linear dichroism to measure the subresolution organization of the cell membrane during formation of the activating (cytolytic) natural killer (NK) cell immune synapse (IS). This approach revealed that the NK cell plasma membrane is convoluted into ruffles at the periphery, but not in the center of a mature cytolytic NK cell IS. Time-lapse imaging showed that the membrane ruffles formed at the initial point of contact between NK cells and target cells and then spread radialy across the intercellular contact as the size of the IS increased, becoming absent from the center of the mature synapse. Understanding the role of such extensive membrane ruff ling in the assembly of cytolytic synapses is an intriguing new goal.
Subject headings and genre
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microtubule-organizing center
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fluorescence
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polarization
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orientation
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activation
Added entries (persons, corporate bodies, meetings, titles ...)
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Vanherberghen, BrunoKTH,Cellens fysik(Swepub:kth)u11pslz9
(author)
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Young, Stephen
(author)
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Taner, Sabrina B.
(author)
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Culley, Fiona I.
(author)
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Schnyder, Tim
(author)
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Neil, Mark A. A.
(author)
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Wuestner, Daniel
(author)
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French, Paul M. W.
(author)
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Davis, Daniel M.
(author)
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Önfelt, BjörnKarolinska Institutet,KTH,Cellens fysik(Swepub:kth)u1tquq43
(author)
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KTHCellens fysik
(creator_code:org_t)
Related titles
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In:Biophysical Journal: Elsevier BV96:2, s. L13-L150006-34951542-0086
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Benninger, Richa ...
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Vanherberghen, B ...
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Young, Stephen
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Taner, Sabrina B ...
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Culley, Fiona I.
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Schnyder, Tim
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Neil, Mark A. A.
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Wuestner, Daniel
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French, Paul M. ...
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Davis, Daniel M.
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Önfelt, Björn
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Biophysical Jour ...
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Royal Institute of Technology
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Karolinska Institutet