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Stereoselective Fri...
Stereoselective Friedel-Crafts alkylation catalyzed by squalene hopene cyclases
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Hammer, Stephan C. (author)
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Dominicus, Joerg M. (author)
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- Syren, Per-Olof (author)
- Universitaet Stuttgart, Germany
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Nestl, Bettina M. (author)
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Hauer, Bernhard (author)
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(creator_code:org_t)
- Elsevier Ltd. 2012
- 2012
- English.
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In: Tetrahedron. - : Elsevier Ltd.. - 0040-4020 .- 1464-5416. ; 68:Copyright (C) 2013 American Chemical Society (ACS). All Rights Reserved., s. 7624-7629
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In org. synthesis the Friedel-Crafts alkylation is of eminent importance, as it is a key reaction in many synthetic routes. A general access to enzymic Friedel-Crafts alkylations would be very beneficial due to the high selectivity of biocatalysts. We used designed polyprenyl Ph ethers to specifically address this reaction by using squalene hopene cyclases as catalysts. Polycyclic products with arom. rings constituting important biol. active compds. were obtained. Our results demonstrate that squalene hopene cyclases can be utilized for Friedel-Crafts alkylations and reveal the potential of these enzymes for chiral Bronsted acid catalysis.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Friedel Crafts alkylation catalyzed squalene hopene cyclase
Publication and Content Type
- ref (subject category)
- art (subject category)
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