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2,2 '-Biindolyl Rea...
2,2 '-Biindolyl Reactions with Aldehydes
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- Koch, Daniel (author)
- Rönninge College, Sweden
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- Koch, Eva (author)
- Karo Bio, Sweden
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- Desarbre, Eric (author)
- Basilea Pharmaceutica Ltd, Switzerland
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- Stensland, Birgitta (author)
- AstraZeneca, Sweden
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- Svensson, Per H. (author)
- RISE,KTH,Tillämpad fysikalisk kemi,SP Process Development, Sweden,Analys och fastfas,Novum, Sweden
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- Bergman, Jan (author)
- Novum, Sweden
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(creator_code:org_t)
- 2016-02-08
- 2016
- English.
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In: European Journal of Organic Chemistry. - : Wiley-VCH Verlag. - 1434-193X .- 1099-0690. ; :7, s. 1389-1396
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- 2,2'-Biindolyl has been condensed with aromatic and aliphatic aldehydes and products featuring 10-membered rings have been obtained. Thus, benzaldehyde gave compound 24a as the primary product, which readily underwent transannular oxidative coupling to 25a. The structures of both compounds were confirmed by X-ray crystallography. The product from 2,2'-biindolyl and formaldehyde under strongly acidic conditions was slightly different leading to compound 11, whose structure also was confirmed by X-ray crystallography. In this case, two molecules of 2,2'-biindolyl reacted with six molecules of formaldehyde.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- Transannular reactions
- Nitrogen heterocycles
- Dehydrogenation
- Carbocycles
- Macrocycles
- Aldehydes
Publication and Content Type
- ref (subject category)
- art (subject category)
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