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  • Ekblad, TorunKTH,Skolan för bioteknologi (BIO) (author)

Positioning of Tc-99m-chelators influences radiolabeling, stability and biodistribution of Affibody molecules

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • Elsevier BV,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-18587
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-18587URI
  • https://doi.org/10.1016/j.bmcl.2009.03.083DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128387URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20100525
  • Affibody molecules represent a novel class of affinity proteins with a high potential as tracers for radio-nuclide molecular imaging. In this comparative structure-property study, a series of Affibody molecules with the Tc-99m-chelators maGGG, maSSS, or maESE attached to the e-amine of the internally positioned K49 was prepared by peptide synthesis, for comparison to molecules with similar chelators positioned at the N-terminus. The conjugates were labeled with Tc-99m and evaluated in vitro and in vivo. It was found that both composition and position of the chelating moiety influence the label stability, biodistribution and targeting properties of HER2-binding Affibody molecules.

Subject headings and genre

  • Affibody molecule
  • Tc chelator
  • Molecular imaging
  • Peptide synthesis
  • malignant-tumors
  • binding-proteins
  • chelators
  • MEDICINE

Added entries (persons, corporate bodies, meetings, titles ...)

  • Orlova, AnnaUppsala universitet,Enheten för biomedicinsk strålningsvetenskap(Swepub:uu)annaorlo (author)
  • Feldwisch, Joachim (author)
  • Wennborg, Anders (author)
  • Eriksson Karlström, AmelieKTH,Molekylär Bioteknologi(Swepub:kth)u10x6l4n (author)
  • Tolmachev, VladimirUppsala universitet,Enheten för biomedicinsk strålningsvetenskap,Institutionen för medicinska vetenskaper(Swepub:uu)vladtolm (author)
  • KTHSkolan för bioteknologi (BIO) (creator_code:org_t)

Related titles

  • In:Bioorganic & Medicinal Chemistry Letters: Elsevier BV19:14, s. 3912-39140960-894X1464-3405

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