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Positioning of Tc-9...
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Ekblad, TorunKTH,Skolan för bioteknologi (BIO)
(author)
Positioning of Tc-99m-chelators influences radiolabeling, stability and biodistribution of Affibody molecules
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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Elsevier BV,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-18587
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-18587URI
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https://doi.org/10.1016/j.bmcl.2009.03.083DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128387URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20100525
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Affibody molecules represent a novel class of affinity proteins with a high potential as tracers for radio-nuclide molecular imaging. In this comparative structure-property study, a series of Affibody molecules with the Tc-99m-chelators maGGG, maSSS, or maESE attached to the e-amine of the internally positioned K49 was prepared by peptide synthesis, for comparison to molecules with similar chelators positioned at the N-terminus. The conjugates were labeled with Tc-99m and evaluated in vitro and in vivo. It was found that both composition and position of the chelating moiety influence the label stability, biodistribution and targeting properties of HER2-binding Affibody molecules.
Subject headings and genre
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Affibody molecule
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Tc chelator
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Molecular imaging
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Peptide synthesis
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malignant-tumors
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binding-proteins
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chelators
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MEDICINE
Added entries (persons, corporate bodies, meetings, titles ...)
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Orlova, AnnaUppsala universitet,Enheten för biomedicinsk strålningsvetenskap(Swepub:uu)annaorlo
(author)
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Feldwisch, Joachim
(author)
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Wennborg, Anders
(author)
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Eriksson Karlström, AmelieKTH,Molekylär Bioteknologi(Swepub:kth)u10x6l4n
(author)
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Tolmachev, VladimirUppsala universitet,Enheten för biomedicinsk strålningsvetenskap,Institutionen för medicinska vetenskaper(Swepub:uu)vladtolm
(author)
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KTHSkolan för bioteknologi (BIO)
(creator_code:org_t)
Related titles
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In:Bioorganic & Medicinal Chemistry Letters: Elsevier BV19:14, s. 3912-39140960-894X1464-3405
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