Multifunctional PLGA/Parylene C Coating for Implant Materials : An Integral Approach for Biointerface Optimization

• Functionalizing implant surfaces is critical for improving their performance. An integrated approach was employed to develop a multifunctional implant:coating based on oxygen plasma-modified parylene C and drug-loaded, biodegradable poly(DL-lactide-co-glycolide) (PLGA). The key functional attributes of the coating (i.e., anti-corrosion, biocompatible, anti-infection, and therapeutic) were thoroughly characterized at each fabrication step by spectroscopic, microscopic, and biologic methods and at different scales, ranging from molecular, through the nano- and microscales to the macroscopic scale. The chemistry of each layer was demonstrated separately, and their mutual affinity was shown to be indispensable for the development of versatile coatings, for implant applications.

Subject headings

TEKNIK OCH TEKNOLOGIER  -- Materialteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Materials Engineering (hsv//eng)

Keyword

parylene C

coating

implant

biointerface

oxygen plasma

PLGA

MG-63

controlled drug elution

Publication and Content Type

ref (subject category)

art (subject category)