onr:"swepub:oai:DiVA.org:kth-194023"
Search: onr:"swepub:oai:DiVA.org:kth-194023" > Analysis of neural ...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Kaucka, MarketaKarolinska Institutet (author)
Analysis of neural crest-derived clones reveals novel aspects of facial development
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- American Association for the Advancement of Science,2016
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-194023
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-194023URI
- https://doi.org/10.1126/sciadv.1600060DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:136315038URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300365URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20161014
- Cranial neural crest cells populate the future facial region and produce ectomesenchyme-derived tissues, such as cartilage, bone, dermis, smooth muscle, adipocytes, and many others. However, the contribution of individual neural crest cells to certain facial locations and the general spatial clonal organization of the ectomesenchyme have not been determined. We investigated how neural crest cells give rise to clonally organized ectomesenchyme and how this early ectomesenchyme behaves during the developmental processes that shape the face. Using a combination of mouse and zebrafish models, we analyzed individual migration, cell crowd movement, oriented cell division, clonal spatial overlapping, and multilineage differentiation. The early face appears to be built from multiple spatially defined overlapping ectomesenchymal clones. During early face development, these clones remain oligopotent and generate various tissues in a given location. By combining clonal analysis, computer simulations, mouse mutants, and live imaging, we show that facial shaping results from an array of local cellular activities in the ectomesenchyme. These activities mostly involve oriented divisions and crowd movements of cells during morphogenetic events. Cellular behavior that can be recognized as individual cell migration is very limited and short-ranged and likely results from cellular mixing due to the proliferation activity of the tissue. These cellular mechanisms resemble the strategy behind limb bud morphogenesis, suggesting the possibility of common principles and deep homology between facial and limb outgrowth.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- NATURVETENSKAP Biologi Cellbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
- NATURVETENSKAP Data- och informationsvetenskap Bioinformatik hsv//swe
- NATURAL SCIENCES Computer and Information Sciences Bioinformatics hsv//eng
- Mouse Embryo
- Craniofacial Development
- Tissue Morphogenesis
- Lineage Analysis
- Cell-Migration
- Stem-Cells
- In-Vivo
- Mechanisms
- Wnt5a
- Head
Added entries (persons, corporate bodies, meetings, titles ...)
- Ivashkin, Evgeny (author)
- Gyllborg, DanielKarolinska Institutet (author)
- Zikmund, Tomas (author)
- Tesarova, Marketa (author)
- Kaiser, Jozef (author)
- Xie, MengKarolinska Institutet (author)
- Petersen, JulianKarolinska Institutet (author)
- Pachnis, Vassilis (author)
- Nicolis, Silvia K. (author)
- Yu, Tian (author)
- Sharpe, Paul (author)
- Arenas, ErnestKarolinska Institutet (author)
- Brismar, HjalmarKarolinska Institutet,KTH,Cellens fysik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1232ew5 (author)
- Blom, HansKTH,Cellens fysik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1qhk3ta (author)
- Clevers, Hans (author)
- Suter, Ueli (author)
- Chagin, Andrei S.Karolinska Institutet (author)
- Fried, KajKarolinska Institutet (author)
- Hellander, AndreasUppsala universitet,Avdelningen för beräkningsvetenskap,Tillämpad beräkningsvetenskap(Swepub:uu)andhe896 (author)
- Adameyko, IgorKarolinska Institutet (author)
- Karolinska InstitutetCellens fysik (creator_code:org_t)
Related titles
- In:Science Advances: American Association for the Advancement of Science2:82375-2548
Internet link
- https://doi.org/10.1126/sciadv.1600060Fulltext
- https://advances.sciencemag.org/content/advances/2/8/e1600060.full.pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-194023
- https://doi.org/10.1126/sciadv.1600060
- http://kipublications.ki.se/Default.aspx?queryparsed=id:136315038
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300365
Find in a library
- Science Advances (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Kaucka, Marketa
- Ivashkin, Evgeny
- Gyllborg, Daniel
- Zikmund, Tomas
- Tesarova, Market ...
- Kaiser, Jozef
- show more...
- Xie, Meng
- Petersen, Julian
- Pachnis, Vassili ...
- Nicolis, Silvia ...
- Yu, Tian
- Sharpe, Paul
- Arenas, Ernest
- Brismar, Hjalmar
- Blom, Hans
- Clevers, Hans
- Suter, Ueli
- Chagin, Andrei S ...
- Fried, Kaj
- Hellander, Andre ...
- Adameyko, Igor
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Cell Biology
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Computer and Inf ...
- and Bioinformatics
- Articles in the publication
- Science Advances
- By the university
- Royal Institute of Technology
- Karolinska Institutet
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
