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Sökning: onr:"swepub:oai:DiVA.org:kth-198474" > Self-assembly and h...

Self-assembly and hybridization mechanisms of DNA with cationic polythiophene

Rubio-Magnieto, Jenifer (författare)
Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
Gebremedhn Azene, Elias (författare)
Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
Knoops, Jeremie (författare)
Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
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Knippenberg, Stefan (författare)
KTH,Teoretisk kemi och biologi,University of Mons, Belgium
Delcourt, Cecile (författare)
Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
Thomas, Amandine (författare)
Institut Charles Gerhardt ICGM, UMR 5253 CNRS-ENSCM-UM, Universite ́ de Montpellier – CC1701, Place Eugene Bataillon, F-34095 Montpellier Cedex 05, France
Richeter, Sebastien (författare)
Institut Charles Gerhardt ICGM, UMR 5253 CNRS-ENSCM-UM, Universite ́ de Montpellier – CC1701, Place Eugene Bataillon, F-34095 Montpellier Cedex 05, France
Mehdi, Ahmad (författare)
Institut Charles Gerhardt ICGM, UMR 5253 CNRS-ENSCM-UM, Universite ́ de Montpellier – CC1701, Place Eugene Bataillon, F-34095 Montpellier Cedex 05, France
Dubois, Philippe (författare)
Laboratory for Polymeric and Composites Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
Lazzaroni, Roberto (författare)
Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
Beljonne, David (författare)
Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
Clement, Sebastien (författare)
Institut Charles Gerhardt ICGM, UMR 5253 CNRS-ENSCM-UM, Universite de Montpellier – CC1701, Place Eugene Bataillon, F-34095 Montpellier Cedex 05, France
Surin, Mathieu (författare)
Laboratory for Chemistry of Novel Materials, Center for Innovation in Materials and Polymers, University of Mons – UMONS, 20 Place du Parc, B-7000 Mons, Belgium
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 (creator_code:org_t)
2015
2015
Engelska.
Ingår i: Soft Matter. - : Royal Society of Chemistry. - 1744-683X .- 1744-6848. ; 11:2, s. 6460-6471
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The combination of DNA and pi-conjugated polyelectrolytes (CPEs) represents a promising approach to develop DNA hybridization biosensors, with potential applications for instance in the detection of DNA lesions and single-nucleotide polymorphisms. Here we exploit the remarkable optical properties of a cationic poly[3-(6'-(trimethylphosphonium)hexyl)thiophene-2,5-diyl] (CPT) to decipher the self-assembly of DNA and CPT. The ssDNA/ CPT complexes have chiroptical signatures in the CPT absorption region that are strongly dependent on the DNA sequence, which we relate to differences in supramolecular interactions between the thiophene monomers and the various nucleobases. By studying DNA-DNA hybridization and melting processes on preformed ssDNA/ CPT complexes, we observe sequence-dependent mechanisms that can yield DNA-condensed aggregates. Heating-cooling cycles show that non-equilibrium mixtures can form, noticeably depending on the working sequence of the hybridization experiment. These results are of high importance for the use of pi-conjugated polyelectrolytes in DNA hybridization biosensors and in polyplexes.

Ämnesord

NATURVETENSKAP  -- Kemi -- Annan kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)

Nyckelord

Soluble Conjugated Polymers
Nucleic-Acid Probes
Optical-Detection
Polyelectrolytes
Sequence
Fluorescence
Proteins
Binding
Condensation
Complexes

Publikations- och innehållstyp

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