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Controlled ring-opening polymerization of lactones and lactides
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- Albertsson, Ann-Christine (author)
- KTH,Polymerteknologi
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- Edlund, Ulrica (author)
- KTH,Polymerteknologi
- Stridsberg, K. (author)
- (creator_code:org_t)
- 2000
- 2000
- English.
- In: Macromolecular Symposia. - 1022-1360 .- 1521-3900. ; 157, s. 39-46
- Journal article (peer-reviewed)
Abstract
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- 1,5-dioxepan-2-one (DXO) is presented as a versatile component in biodegradable polymers for biomedical applications. Copolymerization of DXO and L-lactide yielded a semi-crystalline, yet flexible, material where the extent of crystallinity and erosion characteristics were controlled by an appropriate choice of copolymer composition. Crosslinked PDXO was polymerized as a novel biodegradable elastomer. The degradation behavior of these materials were explored in vitro. Microspheres from poly(DXO-co-L-LA) were prepared and shown to be promising candidates for controlled release. The polymer composition and drug solubility provided effective means of controlling the drug delivery pattern.
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- polymers
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- ref (subject category)
- art (subject category)
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